Anti-5HT1A Receptor Antibody | Boster Immunoleader PA1647 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-5HT1A Receptor Antibody

catalog :

PA1647

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

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product information

Product Name :

Anti-5HT1A Receptor Antibody

Catalog Number :

PA1647

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for 5-hydroxytryptamine receptor 1A(HTR1A) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Rat; Predicted Species: Human, Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT1A Receptor(404-422aa NKDFQNAFKKIIKCKFCRQ), different from the related rat and mouse sequences by one amino acid.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

HTR1A(5-HYDROXYTRYPTAMINE RECEPTOR 1A), also called SEROTONIN 5-HT-1A RECEPTOR or BETA-2-ADRENERGIC RECEPTOR-LIKE PROTEIN G-21, is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor(GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor.The HTR1A gene is located at 5q12.3. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan. Activation of 5-HT-1A receptors has been demonstrated to impair cognition, learning, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. 5-HT-1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1(NK1) receptors and have been shown to inhibit the release of substance P, their endogenous ligand.

Reference :

1. Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ (November 1989). "Deletion Mapping of DNA Markers to a Region of Chromosome 5 That Cosegregates with Schizophrenia". Genomics 5 (4): 940–4. 2. Audero, E., Coppi, E., Mlinar, B., Rossetti, T., Caprioli, A., Banchaabouchi, M. A., Corradetti, R., Gross, C. Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. 3. El Mestikawy, S., Fargin, A., Raymond, J. R., Gozlan, H., Hnatowich, M. The 5-HT(1A) receptor: an overview of recent advances. Neurochem. Res. 16: 1-10, 1991.

Gene Name :

HTR1A

Protein Name :

5-hydroxytryptamine receptor 1A(5-HT-1A/5-HT1A)

Gene Full Name :

5-hydroxytryptamine(serotonin) receptor 1A, G protein-coupled

Synonyms :

5 HT 1A antibody 5 HT receptor 1A antibody 5 HT1A antibody 5 HT1A receptor antibody 5 hydroxytryptamine(serotonin) receptor 1A antibody 5 hydroxytryptamine(serotonin) receptor 1A G protein coupled antibody 5 hydroxytryptamine receptor 1A antibody 5-HT-1A antibody 5-HT1A antibody 5-hydroxytryptamine receptor 1A antibody 5HT 1A antibody 5HT 1A receptor antibody 5HT receptor 1A antibody 5HT1a antibody 5HT1A_HUMAN antibody ADRB2RL1 antibody ADRBRL1 antibody G 21 antibody G protein coupled receptor antibody G-21 antibody Gpcr 18 antibody Gpcr18 antibody Guanine nucleotide binding regulatory protein-coupled receptor antibody HTR1A antibody PFMCD antibody Serotonin 1A receptor antibody Serotonin 5HT1A receptor antibody Serotonin receptor 1A antibody

Uniprot ID :

P08908

more info or order :

Boster Immunoleader product webpage