Anti-MRP1 Antibody | Boster Immunoleader PA1634 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-MRP1 Antibody

catalog :

PA1634

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

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product information

Product Name :

Anti-MRP1 Antibody

Catalog Number :

PA1634

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 1(ABCC1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human MRP1(1514-1531aa, LLQQRGLFYSMAKDAGLV), different from the related rat and mouse sequences by one amino acid.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

ABCC1(ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 1), also called MRP1 or MRP, is a protein that in humans is encoded by the ABCC1 gene. The ABCC1 is a member of the superfamily of ATP-binding cassette(ABC) transporters. The ABCC1 is a plasma membrane drug-efflux pump.The ABCC1 gene is mapped to chromosome 16p13.1 by isotopic in situ hybridization. ABCC1 functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates and it also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Blocking ABCC1 efflux pumps increases the susceptibility of the cells to the toxic effects of unconjugated bilirubin, suggesting that ABCC1 is an important protector in this scenario. ABCC1 clears beta-amyloid from brains of mice and can be activated by thiethylperazine. And Chemotaxis assays show that ABCC1-mediated transport of S1P influenced mast-cell migration, but not mast-cell degranulation.

Reference :

1. Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., Deeley, R. G. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650-1654, 1992. 2. Conrad, S., Kauffmann, H.-M., Ito, K., Deeley, R. G., Cole, S. P. C., Schrenk, D. Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution. J. Hum. Genet. 46: 656-663, 2001. 3. Grant, C. E., Kurz, E. U., Cole, S. P. C., Deeley, R. G. Analysis of the intron-exon organization of the uman multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA. Genomics 45: 368-378, 1997.

Gene Name :

ABCC1

Protein Name :

Multidrug resistance-associated protein 1

Gene Full Name :

ATP-binding cassette, sub-family C(CFTR/MRP), member 1

Synonyms :

ABC 29 antibody ABC29 antibody ABCC 1 antibody ABCC antibody ABCC1 antibody ATP binding cassette sub family C(CFTR/MRP) member 1 antibody ATP binding cassette sub-family C member 1 antibody ATP-binding cassette sub-family C member 1 antibody DKFZp686N04233 antibody DKFZp781G125 antibody GS X antibody GSX antibody Leukotriene C(4) transporter antibody LTC4 transporter antibody MRP 1 antibody MRP antibody MRP1_HUMAN antibody Multidrug resistance associated protein 1 antibody Multidrug resistance protein antibody Multidrug resistance-associated protein 1 antibody Multiple drug resistance associated protein antibody Multiple drug resistance protein 1 antibody

Uniprot ID :

P33527

more info or order :

Boster Immunoleader product webpage