Boster Immunoleader

antibody

Anti-HSD17B1 Antibody

PA1613

100 ug/vial

200 USD

polyclonal

rabbit

mouse, rat

Anti-HSD17B1 Antibody

PA1613

Polyclonal

Rabbit IgG polyclonal antibody for Estradiol 17-beta-dehydrogenase 1(HSD17B1) detection. Tested with WB in Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: mouse, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Mouse, Rat

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence in the middle region of rat HSD17B1(206-225aa ERADAQTRHLFAHYQRGYEQ), different from the related mouse sequence by one amino acid.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

HSD17B1(17-BETA-HYDROXYSTEROID DEHYDROGENASE I), also known as 17-beta-hydroxysteroid dehydrogenase or 17-ketosteroid reductase, is an enzyme that is responsible for the interconversion of estrone(E1) and estradiol(E2) as well as the interconversion of androstenedione and testosterone. Its cytogenetic location is 17q21.2. HSD17B1 gene expression is detected in 34 of 42(81%) adenomas in all tumor subtypes; HSD17B2 mRNA is detected in 18 of 42(43%) adenomas but not in prolactinomas. Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies. All 4 HSD17B isoforms are variably expressed in human anterior pituitary adenomas, which also show HSD17B enzyme activity, suggesting that HSD17B may play an important role in regulating the local cellular levels of estradiol.

1. Berube, D., Luu-The, V., Simard, J., Gagne, R., Labrie, F. Localization of the beta-estradiol dehydrogenase genes to q11-q12 of chromosome 17. (Abstract) Cytogenet. Cell Genet. 51: 962 only, 1989. 2. Geissler, W. M., Davis, D. L., Wu, L., Bradshaw, K. D., Patel, S., Mendonca, B. B., Elliston, K. O., Wilson, J. D., Russell, D. W., Andersson, S. Male pseudohermaphroditism caused by mutations of testicular 17-beta-hydroxysteroid dehydrogenase 3. Nature Genet. 7: 34-39, 1994. 3. Harkness, R. A., Thistlethwaite, D., Darling, J. A. B., Skakkebaek, N. E., Corker, C. S. Neutral 17-beta-hydroxysteroid oxidoreductase deficiency in testes causing male pseudohermaphroditism in an infant. J. Inherit. Metab. Dis. 2: 51-54, 1979.

HSD17B1

Estradiol 17-beta-dehydrogenase 1

hydroxysteroid(17-beta) dehydrogenase 1

17 beta HSD 1 antibody 17 beta hydroxysteroid dehydrogenase type 1 antibody 17-beta-HSD 1 antibody 17-beta-hydroxysteroid dehydrogenase type 1 antibody 20 alpha-hydroxysteroid dehydrogenase antibody 20-alpha-HSD antibody DHB1_HUMAN antibody E17KSR antibody E2DH antibody EDH17B1 antibody EDH17B2 antibody EDHB17 antibody Estradiol 17 beta dehydrogenase 1 antibody Estradiol 17-beta-dehydrogenase 1 antibody HSD17 antibody HSD17B1 antibody Hydroxysteroid(17 beta) dehydrogenase 1 antibody MGC13814 antibody Placental 17 beta hydroxysteroid dehydrogenase antibody Placental 17-beta-hydroxysteroid dehydrogenase antibody SDR28C1 antibody Short chain dehydrogenase/reductase family 28CE,member 1 antibody

P51657