Boster Immunoleader

antibody

Anti-5HT3A receptor Antibody

PA1610

100 ug/vial

200 USD

polyclonal

rabbit

western blot, immunohistochemistry - paraffin section

Anti-5HT3A receptor Antibody

PA1610

Polyclonal

Rabbit IgG polyclonal antibody for 5-hydroxytryptamine receptor 3A(HTR3A) detection. Tested with WB, IHC-P in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Concentration: 0.5-1μg/ml; Tested Species: Human

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence in the middle region of human5HT3A receptor(140-154aa RHQGEVQNYKPLQVV).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

HTR3A(5-HYDROXYTRYPTAMINE RECEPTOR 3A), also called SEROTONIN 5-HT-3 RECEPTOR, is a member of the ligand-gated ion channel receptor superfamily. HTR3A is a neurotransmitter in the central and peripheral nervous systems that plays a role in many physiologic processes such as sleep, appetite, thermoregulation, pain perception, hormone secretion, and sexual behavior. Using fluorescence in situ hybridization, the HTR3 gene is assigned to 11q23.1-q23.2. The single-channel conductance for homomers of HTR3A is 0.4 pS. Replacement of 3 arginine residues unique to the HA-stretch of the HTR3A subunit by their HTR3B subunit counterparts increases single-channel conductance 28-fold. Ultrastructural studies of the Torpedo nicotinic acetylcholine receptor indicated that the key residues might frame narrow openings that contribute to the permeation pathway. The genomic structure of the HTR3A gene contains 7 exons and spans approximately 14.5 kb.

1. Bruss, M., Eucker, T., Gothert, M., Bonisch, H. Exon-intron organization of the human 5-HT-3A receptor gene. Neuropharmacology 39: 308-315, 2000. 2. Kelley, S. P., Dunlop, J. I., Kirkness, E. F., Lambert, J. J., Peters, J. A. A cytoplasmic region determines single-channel conductance in 5-HT(3) receptors. Nature 424: 321-324, 2003. 3. Maricq, A. V., Peterson, A. S., Brake, A. J., Myers, R. M., Julius, D. Primary structure and functional expression of the 5HT-3 receptor, a serotonin-gated ion channel. Science 254: 432-437, 1991.

HTR3A

5-hydroxytryptamine receptor 3A(5-HT3-A/5-HT3A)

5-hydroxytryptamine(serotonin) receptor 3A, ionotropic

5 HT 3 antibody 5 HT3 receptor antibody 5 HT3A antibody 5 HT3A receptor antibody 5 HT3R antibody 5 HT3RA antibody 5 hydroxytryptamine(serotonin) receptor 3A antibody 5-HT-3 antibody 5-HT3-A antibody 5-HT3A antibody 5-HT3R antibody 5-hydroxytryptamine receptor 3 antibody 5-hydroxytryptamine receptor 3A antibody 5HT 3 antibody 5HT 3A antibody 5HT receptor antibody 5HT3 serotonin receptor antibody 5HT3A_HUMAN antibody 5HT3R antibody HTR3 antibody Htr3a antibody Serotonin gated ion channel receptor antibody Serotonin receptor 3A antibody Serotonin-gated ion channel receptor 3a antibody Serotonin-gated ion channel receptor antibody

P46098