Boster Immunoleader

antibody

Anti-Ionotropic Glutamate receptor 2 Antibody

PA1598

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section

Anti-Ionotropic Glutamate receptor 2 Antibody

PA1598

Polyclonal

Rabbit IgG polyclonal antibody for Glutamate receptor 2(GRIA2) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Concentration: 0.5-1μg/ml; Tested Species: Rat; Predicted Species: Human, Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence in the middle region of human Ionotropic Glutamate receptor 2(260-277aa FQIVDYDDSLVSKFIERW), identical to the related rat and mouse sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

GLUR2, also called Glutamate receptors and mediated by a G-protein that inhibits adenylate cyclase activity, sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate(AMPA), are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. GLUR2's cytogenetic location is 4q32.1. The crystal structures of the GLUR2 ligand-binding core in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPA and glutamate. As previously demonstrated in rats, the GLUR2 in human has RNA editing, posttranscriptional change of the sequence at the mRNA level. And interruption of the interaction between C-terminal Glur2 and PDZ domain-containing proteins, such as GRIP and PICK1, resulted in increased AMPA receptor-mediated excitatory transmission and blockade of long-term depression.GLUR2 plays a major role in depression at synapses in which glutamate remains in the synaptic cleft for prolonged periods of time during normal operation of the synapse.

1. Armstrong, N., Gouaux, E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron 28: 165-181, 2000. 2. Biou, V., Bhattacharyya, S., Malenka, R. C. Endocytosis and recycling of AMPA receptors lacking GluR2/3. Proc. Nat. Acad. Sci. 105: 1038-1043, 2008. 3. Mameli, M., Balland, B., Lujan, R., Luscher, C. Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science 317: 530-533, 2007.

GRIA2

Glutamate receptor 2(GluR-2)

glutamate receptor, ionotropic, AMPA 2

AMPA 2 antibody AMPA selective glutamate receptor 2 antibody AMPA-selective glutamate receptor 2 antibody AMPA2 antibody Glu R2 antibody Glu RB antibody GluA2 antibody GluR 2 antibody GluR B antibody GluR B flop antibody GluR K2 antibody GluR-2 antibody GluR-B antibody GluR-K2 antibody GLUR2 antibody GluRB antibody Glutamate receptor 2 antibody Glutamate receptor ionotropic AMPA 2 antibody Glutamate receptor ionotropic AMPA2 antibody Glutamate receptor ionotropic antibody Gria 2 antibody Gria2 antibody GRIA2_HUMAN antibody HBGR 2 antibody HBGR2 antibody

P42262