Boster Immunoleader

antibody

Anti-GBP1 Antibody

PA1550

100 ug/vial

200 USD

polyclonal

rabbit

Anti-GBP1 Antibody

PA1550

Polyclonal

Rabbit IgG polyclonal antibody for Interferon-induced guanylate-binding protein 1(GBP1) detection. Tested with WB in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human GBP1(566-589aa QKESRIMKNEIQDLQTKMRRRKAC).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Interferons induce a large number of genes in their target cells, including those coding for guanylate-binding proteins(GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides(GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. The 593-amino acid GBP1 protein shares 77% and 88% identity with GBP2 and GBP3, respectively. All GBPs, including GBP1, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases. The GBP1 gene to the GBP gene cluster on chromosome 1p22.2. It is located telomeric to GBP2 and centromeric to GBP3. High expression of GBP1, GBP2, and GBP3 are in endothelial cells after stimulation with IFNG, TNF, or IL1B .

1. Cheng, Y.-S. E., Patterson, C. E., Staeheli, P.Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.Molec. Cell. Biol. 11: 4717-4725, 1991. 2. Olszewski, M. A., Gray, J., Vestal, D. J.In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.J. Interferon Cytokine Res. 26: 328-352, 2006. 3. Tripal, P., Bauer, M., Naschberger, E., Mortinger, T., Hohenadl, C., Cornali, E., Thurau, M., Sturzl, M.Unique features of different members of the human guanylate-binding protein family.J. Interferon Cytokine Res. 27: 44-52, 2007.

GBP1

Interferon-induced guanylate-binding protein 1

guanylate binding protein 1, interferon-inducible

GBP 1 antibody GBP-1 antibody GBP1 antibody GBP1_HUMAN antibody GTP binding protein 1 antibody GTP-binding protein 1 antibody Guanine nucleotide binding protein 1 antibody Guanine nucleotide-binding protein 1 antibody Guanylate binding protein 1 antibody Guanylate binding protein 1 interferon inducible 67kDa antibody Guanylate binding protein 1 interferon inducible antibody HuGBP 1 antibody HuGBP-1 antibody HuGBP1 antibody Interferon induced guanylate binding protein 1 antibody Interferon-induced guanylate-binding protein 1 antibody OTTHUMP00000012352 antibody

P32455