Anti-SLC10A1 Antibody | Boster Immunoleader PA1532 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-SLC10A1 Antibody

catalog :

PA1532

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-SLC10A1 Antibody

Catalog Number :

PA1532

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Sodium/bile acid cotransporter(SLC10A1) detection. Tested with WB in Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: mouse, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Mouse, Rat

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence in the middle region of mouse SLC10A1(238-252aa YILSALFRLNPSCRR), different from the related rat sequence by one amino acid.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Na+-taurocholate cotransporting polypeptide(NTCP), also known as SLC10A1(Solute carrier family 10, member 1) is the major bile acid uptake system in human hepatocytes. NTCP and the ileal transporter ASBT(apical sodium-dependent bile acid transporter) are two sodium-dependent transporters critical for the enterohepatic circulation of bile acids. The hASBT gene is known to be activated by the glucocorticoid receptor(GR). Ho RH et al. indicates functionally important polymorphisms in NTCP exist and that the likelihood of being carriers of such polymorphisms is dependent on ethnicity.

Reference :

1. Eloranta JJ, Jung D, Kullak-Ublick GA (2006). "The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism.". Mol. Endocrinol. 20 (1): 65–79. 2. Ho RH, Leake BF, Roberts RL, et al. (2004). "Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition.". J. Biol. Chem. 279 (8): 7213–22.

Gene Name :

SLC10A1

Protein Name :

Sodium/bile acid cotransporter

Gene Full Name :

solute carrier family 10(sodium/bile acid cotransporter family), member 1

Synonyms :

Cell growth-inhibiting gene 29 protein antibody Growth inhibiting protein 29 antibody Na/bile acid cotransporter antibody Na/taurocholate transport protein antibody Na(+)/bile acid cotransporter antibody Na(+)/taurocholate transport protein antibody Na/taurocholate cotransporting polypeptide antibody NTCP antibody NTCP_HUMAN antibody NTCP1 antibody SLC10A1 antibody Sodium/bile acid cotransporter antibody Sodium/taurocholate cotransporter antibody Sodium/taurocholate cotransporting polypeptide antibody Solute carrier family 10(sodium/bile acid cotransporter family) member 1 antibody Solute carrier family 10 member 1 antibody

Uniprot ID :

O08705

more info or order :

Boster Immunoleader product webpage