Boster Immunoleader

antibody

Anti-Caveolin-3 Antibody

PA1523

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section

Anti-Caveolin-3 Antibody

PA1523

Polyclonal

Rabbit IgG polyclonal antibody for Caveolin-3(CAV3) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Concentration: 0.5-1μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human Caveolin-3(109-128aa HIYSLCIRTFCNPLFAALGQ), identical to the related rat and mouse sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

CAV3, Caveolin-3, is a protein that in humans is encoded by the CAV3 gene. The CAV3 gene contains 2 exons. This gene is mapped to chromosome 3p25.3. This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C(LGMD-1C), Hyperkalemia or rippling muscle disease(RMD). Other mutations in Caveolin causes Long QT Syndrome. Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.

1. Betz, R. C., Schoser, B. G. H., Kasper, D., Ricker, K., Ramirez, A., Stein, V., Torbergsen, T., Lee, Y.-A., Nothen, M. M., Wienker, T. F., Malin, J.-P., Propping, P., Reis, A., Mortier, W., Jentsch, T. J., Vorgerd, M., Kubisch, C.Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease.Nature Genet. 28: 218-219, 2001. 2. Gazzerro, E., Sotgia, F., Bruno, C., Lisanti, M. P., Minetti, C.Caveolinopathies: from the biology of caveolin-3 to human diseases.Europ. J. Hum. Genet. 18: 137-145, 2010. 3. Hayashi, T., Arimura, T., Ueda, K., Shibata, H., Hohda, S., Takahashi, M., Hori, H., Koga, Y., Oka, N., Imaizumi, T., Yasunami, M., Kimura, A.Identification and functional analysis of a caveolin-3 mutation associated with familial hypertrophic cardiomyopathy.Biochem. Biophys. Res. Commun. 313: 178-184, 2004.

CAV3

Caveolin-3

caveolin 3

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P56539