Boster Immunoleader

antibody

Anti-CaMKK Antibody

PA1520

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section

Anti-CaMKK Antibody

PA1520

Polyclonal

Rabbit IgG polyclonal antibody for Calcium/calmodulin-dependent protein kinase kinase 1(CAMKK1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, mouse, rat

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Concentration: 0.5-1μg/ml; Tested Species: Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of mouse CaMKK(10-31aa QDPRAELVDRVAAINVAHLEEA), different from the related human sequence by three amino acids, and from the related rat sequence by two amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

CAMKK1, Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene. The CAMKK1 gene is mapped to chromosome 17. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.Camkk1binds calmodulin and activated Camk4 with a 6-fold increase in total activity and a 100-fold increase in Camk4 Ca(2+)-independent activity. Camkk1 catalyzed a 10-fold increase in the total activity of Camk1 and had no effect on Camk2. Cotransfection of COS-7 cells with Camkk1 and Camk4 resulted in a 14-fold increase in CRE-binding protein-dependent transcription compared with Camk4 alone, suggesting that Camkk1 enhances Camk4-mediated transcriptional regulation.

1. Blaeser, F., Sanders, M. J., Truong, N., Ko, S., Wu, L. J., Wozniak, D. F., Fanselow, M. S., Zhuo, M., Chatila, T. A.Long-term memory deficits in pavlovian fear conditioning in Ca(2+)/calmodulin kinase kinase alpha-deficient mice.Molec. Cell. Biol. 26: 9105-9115, 2006. 2. Tokumitsu, H., Enslen, H., Soderling, T. R.Characterization of a Ca(2+)/calmodulin-dependent protein kinase cascade: molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase.J. Biol. Chem. 270: 19320-19324, 1995.

CAMKK1

Calcium/calmodulin-dependent protein kinase kinase 1(CaM-KK 1/CaM-kinase kinase 1/CaMKK 1)

calcium/calmodulin-dependent protein kinase kinase 1, alpha

Ca2+/calmodulin-dependent protein kinase kinase alpha antibody Calcium/calmodulin dependent protein kinase kinase antibody Calcium/calmodulin dependent protein kinase kinase 1 alpha antibody Calcium/calmodulin dependent protein kinase kinase 1 antibody Calcium/calmodulin dependent protein kinase kinase alpha antibody Calcium/calmodulin-dependent protein kinase kinase 1 antibody Calcium/calmodulin-dependent protein kinase kinase alpha antibody CaM kinase kinase alpha antibody CaM-kinase IV kinase antibody CaM-kinase kinase 1 antibody CaM-kinase kinase alpha antibody CaM-KK 1 antibody CaM-KK alpha antibody CaMKK 1 antibody CaMKK alpha antibody CAMKK alpha protein antibody CaMKK antibody CAMKK1 antibody CAMKKA antibody DKFZp761M0423 antibody KKCC1_HUMAN antibody MGC34095 antibody OTTMUSP00000006419 antibody

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