Anti-Ribonuclease A Antibody | Boster Immunoleader PA1507 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Ribonuclease A Antibody

catalog :

PA1507

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Ribonuclease A Antibody

Catalog Number :

PA1507

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Ribonuclease pancreatic(RNASE1) detection. Tested with WB in Human.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence in the middle region of human Ribonuclease A(72-90aa NTFVHEPLVDVQNVCFQEK).

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

RIBONUCLEASE A FAMILY, 1(Ribonuclease pancreatic) is an enzyme that in humans is encoded by the RNASE1 gene. By genomic sequence analysis, RNASE1 gene is mapped the to chromosome 14q11.2, where it is linked to 7 other RNase A superfamily genes. Monomeric human pancreatic RNase, devoid of any biological activity other than its RNA degrading ability, was engineered into a dimeric protein with a cytotoxic action on mouse and human tumor cells, but lacking any appreciable toxicity on mouse and human normal cells. This dimeric variant of human pancreas RNase selectively sensitizes to apoptotic death cells derived from a human thyroid tumor. Because of its selectivity for tumor cells, and because of its human origin, this protein represents a potentially very attractive, novel tool for anticancer therapy.

Reference :

1. Zhang, J., Dyer, K. D., Rosenberg, H. F. RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. Nucleic Acids Res. 30: 1169-1175, 2002. 2. Piccoli, R., Di Gaetano, S., De Lorenzo, C., Grauso, M., Monaco, C., Spalletti-Cernia, D., Laccetti, P., Cinatl, J., Matousek, J., D'Alessio, G. A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells. Proc. Nat. Acad. Sci. 96: 7768-7773, 1999.

Gene Name :

RNASE1

Protein Name :

Ribonuclease pancreatic

Gene Full Name :

ribonuclease, RNase A family, 1(pancreatic)

Synonyms :

HP-RNase antibody Pancreatic ribonuclease antibody Rib 1 antibody RIB-1 antibody Rib1 antibody Ribonuclease 1 antibody Ribonuclease A antibody Ribonuclease a family 1 antibody Ribonuclease pancreatic antibody Ribonuclease RNase A family 1 antibody Ribonuclease RNase A family 1 pancreatic antibody RNAS1_HUMAN antibody RNase 1 antibody RNAse A antibody RNase UpI-1 antibody Rnase1 antibody RNAseA antibody

Uniprot ID :

P07998

more info or order :

Boster Immunoleader product webpage