Anti-Caspase 4 Antibody | Boster Immunoleader PA1490 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Caspase 4 Antibody

catalog :

PA1490

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot, immunohistochemistry - paraffin section

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Caspase 4 Antibody

Catalog Number :

PA1490

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Caspase-4(CASP4) detection. Tested with WB, IHC-P in Human.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase 4(104-124aa DALKLCPHEEFLRLCKERAEE).

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue, and belongs to a family of cysteine proteases called caspases. The Caspase 4 gene is mapped to a P1 clone containing the ICE gene, which is located at chromosome 11q22.2-q22.3. It contains 8 coding exons.The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5(and the murine homolog caspase 11), with a role in the immune system.

Reference :

1. Kajiwara, Y., Akram, A., Katsel, P., Haroutunian, V., Schmeidler, J., Beecham, G., Haines, J. L., Pericak-Vance, M. A., Buxbaum, J. D.FE65 binds teashirt, inhibiting expression of primate-specific caspase-4. PLoS One 4:e5071, 2009. 2. Kamens, J., Paskind, M., Hugunin, M., Talanian, R. V., Allen, H., Banach, D., Bump, N., Hackett, M., Johnston, C. G., Li, P., Mankovich, J. A., Terranova, M., Ghayur, T.Identification and characterization of ICH-2, a novel member of the interleukin-1-beta-converting enzyme family of cysteine proteases.J. Biol. Chem. 270: 15250-15256, 1995.

Gene Name :

CASP4

Protein Name :

Caspase-4

Gene Full Name :

caspase 4, apoptosis-related cysteine peptidase

Synonyms :

Apoptosis related cysteine peptidase antibody Apoptotic cysteine protease Mih1/TX antibody CASP 4 antibody CASP 4 antibody CASP-4 antibody CASP4 antibody CASP4_HUMAN antibody Caspase 4 apoptosis related cysteine peptidase antibody Caspase-4 subunit 2 antibody Caspase4 antibody ICE(rel) II antibody ICE(rel)-II antibody ICE(rel)II antibody ICEREL II antibody ICERELII antibody ICH 2 antibody ICH 2 protease antibody ICH2 antibody Mih1/TX antibody Mih1/TX antibody Protease ICH-2 antibody Protease TX antibody TX antibody TX protease antibody

Uniprot ID :

P49662

more info or order :

Boster Immunoleader product webpage