Boster Immunoleader

antibody

Anti-ADAMTS4 Antibody

PA1479

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-ADAMTS4 Antibody

PA1479

Polyclonal

Rabbit IgG polyclonal antibody for A disintegrin and metalloproteinase with thrombospondin motifs 4(ADAMTS4) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, mouse, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human ADAMTS4(820-837aa RRAQILEILRRRPWAGRK), different from the related rat and mouse sequences by three amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene. ADAMTS4 is a member of the large ADAMTS family of zinc-dependent proteases. The human ADAMTS4 gene is mapped to chromosome 1 by somatic cell hybrid analysis. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

1. Hurskainen, T. L., Hirohata, S., Seldin, M. F., Apte, S. S.ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases: general features and genomic distribution of the ADAM-TS family.J. Biol. Chem. 274: 25555-25563, 1999. 2. Tang, B. L., Hong, W.ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats.FEBS Lett. 445: 223-225, 1999. 3. Tortorella, M. D., Burn, T. C., Pratta, M. A., Abbaszade, I., Hollis, J. M., Liu, R., Rosenfeld, S. A., Copeland, R. A., Decicco, C. P., Wynn, R., Rockwell, A., Yang, F., and 16 others.Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.Science 284: 1664-1666, 1999.

ADAMTS4

A disintegrin and metalloproteinase with thrombospondin motifs 4(ADAM-TS 4/ADAM-TS4/ADAMTS-4)

ADAM metallopeptidase with thrombospondin type 1 motif, 4

A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody A disintegrin like and metalloprotease(reprolysin type) with thrombospondin type 1 motif 4 antibody A disintegrin like and metalloprotease with thrombospondin type 1 motif 4 antibody ADAM metallopeptidase with thrombospondin type 1 motif 4 antibody ADAM TS 4 antibody ADAM TS4 antibody ADAM-TS 4 antibody ADAM-TS4 antibody ADAMTS 2 antibody ADAMTS 4 antibody ADAMTS-4 antibody ADAMTS2 antibody ADAMTS4 antibody ADAMTS4 protein antibody ADMP 1 antibody ADMP-1 antibody ADMP1 antibody Aggrecanase 1 antibody Aggrecanase-1 antibody Aggrecanase1 antibody ATS4_HUMAN antibody KIAA0688 antibody

O75173