Boster Immunoleader

antibody

Anti-IL12 p40 Antibody

PA1468

100 ug/vial

200 USD

polyclonal

rabbit

Anti-IL12 p40 Antibody

PA1468

Polyclonal

Rabbit IgG polyclonal antibody for Interleukin-12 subunit beta(IL12B) detection. Tested with WB in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human IL12 p40(23-40aa IWELKKDVYVVELDWYPD).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

IL-12, Interleukin 12, heterodimerizes with the IL12 p35 subunit to form IL12 and with the IL23 p19 subunit to form IL23. IL12b p 40 exists as a monomer and as a homodimer. This gene encodes a subunit of Interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The IL-12b gene contains 8 exons, the first and last of which are noncoding. By PCR analysis of DNA from rodent/human cell hybrids containing intact chromosomes or translocation chromosomes, the IL-12b gene is mapped to 5q31-q33.This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.

1. Gunsten, S., Mikols, C. L., Grayson, M. H., Schwendener, R. A., Agapov, E., Tidwell, R. M., Cannon, C. L., Brody, S. L., Walter, M. J.IL-12 p80-dependent macrophage recruitment primes the host for increased survival following a lethal respiratory viral infection.Immunology 126: 500-513, 2008. 2. Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K., Zonin, F., Vaisberg, E., and 13 others.Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.Immunity 13: 715-725, 2000. 3. Sieburth, D., Jabs, E. W., Warrington, J. A., Li, X., Lasota, J., LaForgia, S., Kelleher, K., Huebner, K., Wasmuth, J. J., Wolf, S. F.Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5.Genomics 14: 59-62, 1992.

IL12B

Interleukin-12 subunit beta(IL-12B)

interleukin 12B(natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

40 kD Subunit antibody CLMF 2 antibody CLMF antibody CLMF p40 antibody CLMF2 antibody Cytotoxic lymphocyte maturation factor 2 antibody Cytotoxic lymphocyte maturation factor 2 p40 antibody Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody HGNC:5970 antibody IL 12 subunit p40 antibody IL 12B antibody IL-12 subunit p40 antibody IL-12B antibody IL12 subunit p40 antibody IL12B antibody IL12B_HUMAN antibody Interleukin 12 beta chain antibody Interleukin 12 p40 antibody Interleukin 12 subunit beta antibody Interleukin 12B antibody Interleukin-12 subunit beta antibody Natural killer cell stimulatory factor 2 antibody NK cell stimulatory factor chain 2 antibody NKSF 2 antibody NKSF antibody NKSF2 antibody p40 antibody TcMF antibody TSF antibody

P29460