Boster Immunoleader

antibody

Anti-Caspase-6(P18) Antibody

PA1441-1

100 ug/vial

200 USD

polyclonal

rabbit

mouse, rat

western blot, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

Anti-Caspase-6(P18) Antibody

PA1441-1

Polyclonal

Rabbit IgG polyclonal antibody for Caspase-6(CASP6) detection. Tested with WB, IHC-P, IHC-F in Mouse; Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: mouse, rat

WB,IHC-P,IHC-F

Concentration: 0.1-0.5μg/ml; Tested Species: Mouse, Rat

Concentration: 0.5-1μg/ml; Tested Species: Mouse, Rat

Concentration: 0.5-1μg/ml; Tested Species: Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of rat Caspase-6(P18)(7-27aa FYRSREVLDPAEQYKMDHKRR), different from the related mouse sequence by two amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P) and IHC(F).

Caspase 6 is an enzyme that in humans is encoded by the caspase 6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease(caspase) family. Using radiation hybrid mapping, the Caspase 6 gene is localized to human chromosome 4q25-q26. Caspase 6 functions as a downstream enzyme in the caspase activation cascade. And Caspase 6 can cleave lamin A to its signature apoptotic fragment.

1. Fernandes-Alnemri, T., Litwack, G., Alnemri, E. S.Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.Cancer Res. 55: 2737-2742, 1995. 2. Nikolaev, A., McLaughlin, T., O'Leary, D. D. M., Tessier-Lavigne, M.APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 457: 981-989, 2009. 3. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., Dixit, V. M.The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.J. Biol. Chem. 271: 16443-16446, 1996.

CASP6

Caspase-6

caspase 6, apoptosis-related cysteine peptidase

Apoptosis Related Cysteine Protease antibody Apoptotic cysteine protease MCH2 antibody Apoptotic protease MCH 2 antibody Apoptotic protease Mch-2 antibody Apoptotic protease MCH2 antibody Casp 6 antibody CASP-6 antibody Casp6 antibody Caspase 6 antibody Caspase 6 apoptosis related cysteine protease antibody Caspase 6 precursor antibody Caspase 6, apoptosis related cysteine peptidase antibody Caspase-6 subunit p18 antibody Caspase6 antibody Human cysteine protease Mch2 isoform alpha antibody Mch 2 antibody Mch2 antibody OTTHUMP00000162742 antibody OTTHUMP00000162743 antibody

O35397