Anti-Cytochrome P450 2D6 Antibody | Boster Immunoleader PA1397 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Cytochrome P450 2D6 Antibody

catalog :

PA1397

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Cytochrome P450 2D6 Antibody

Catalog Number :

PA1397

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Cytochrome P450 2D6(CYP2D6) detection. Tested with WB, IHC-P in Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: rat Predicted to work with: mouse

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Rat; Predicted Species: Mouse

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence in the middle region of mouse Cytochrome P450 2D6(194-214aa FACRFEYNDPRFIRLLDLLKD), identical to the related rat sequence.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

Cytochrome P450 2D6(CYP2D6) is one of the most important enzymes involved in the metabolism of xenobiotics in the body. It is a member of Cytochrome P450, family 2, subfamily D, polypeptide 6. Its gene is mapped to chromosome 22q13.1. It has got 497 amino acid proteins which shares 73% sequence identity with the rat protein. CYP2D6 is highly expressed in human liver. CYP2D6 is the major isozyme involved in the formation of N-hydroxyprocainamide, a metabolite potentially involved in the drug-induced lupus syndrome observed with procainamide

Reference :

1. Entrez Gene: CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6". 2. Distlerath, L. M., Guengerich, F. P.Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme.Proc. Nat. Acad. Sci.81: 7348-7352, 1984. 3. Gonzalez, F. J., Matsunaga, T., Nagata, K., Meyer, U. A., Nebert, D. W., Pastewka, J., Kozak, C. A., Gillette, J., Gelboin, H. V., Hardwick, J. P.Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.DNA6: 149-161, 1987.

Gene Name :

CYP2D6

Protein Name :

Cytochrome P450 2D6

Gene Full Name :

cytochrome P450, family 2, subfamily D, polypeptide 6

Synonyms :

CPD6 antibody CYP2D antibody CYP2D6 antibody CYP2D7AP antibody CYP2D7BP antibody CYP2D7P2 antibody CYP2D8P2 antibody CYP2DL1 antibody CYPIID6 antibody Cytochrome P450 DB1 antibody Cytochrome P450 family 2 subfamily D polypeptide 6 antibody Debrisoquine 4 hydroxylase antibody EC 1.14.14.1 antibody Flavoprotein linked monooxygenase antibody MGC120389 antibody MGC120390 antibody Microsomal monooxygenase antibody P450 DB1 antibody P450C2D antibody P450DB1 antibody Xenobiotic monooxygenase antibody

Uniprot ID :

P10635

more info or order :

Boster Immunoleader product webpage