Boster Immunoleader

antibody

Anti-HSD17B6 Antibody

PA1386

100 ug/vial

200 USD

polyclonal

rabbit

western blot, immunohistochemistry - paraffin section

info changed 20150507

Anti-HSD17B6 Antibody

PA1386

Polyclonal

Rabbit IgG polyclonal antibody for 17-beta-hydroxysteroid dehydrogenase type 6(HSD17B6) detection. Tested with WB, IHC-P in Human.

200 USD

Rabbit IgG

100 ug/vial

Liquid

No cross reactivity with other proteins.

Reacts with: human

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Concentration: 0.5-1μg/ml; Tested Species: Human

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human HSD17B6(300-317aa SLADYILTRSWPKPAQAV).

Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4.

Immunogen affinity purified.

At -20˚C for one year, at 4˚C for one month. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene. The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. Baker ME et al point out expression of 17beta-HSDs had an important role in the early evolution of the physiological response to androgens and estrogens. Biswas and Russell concluded that 17beta-HSD6 and RoDH play opposing roles in androgen action; 17beta-HSD6 inactivates 3alpha-adiol by conversion to androsterone and RoDH activates 3alpha-adiol by conversion to dihydrotestosterone. The synthesis of an active steroid hormone by back conversion of an inactive metabolite represents a potentially important mechanism by which the steady state level of a transcriptional effector can be regulated.

1. Baker ME (Feb 2001). "Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action". Mol Cell Endocrinol 171 (1-2): 211–5. doi:10.1016/S0303-7207(00)00414-7. PMID 11165032. 2. Biswas, M. G., Russell, D. W. Expression cloning and characterization of oxidative 17-beta- and 3-alpha –hydroxysteroid dehydrogenases from rat and human prostate. J. Biol. Chem. 272: 15959-15966, 1997.

HSD17B6

17-beta-hydroxysteroid dehydrogenase type 6(17-beta-HSD 6/17-beta-HSD6)

hydroxysteroid(17-beta) dehydrogenase 6 homolog(mouse)

17-beta-HSD 6 antibody 17-beta-HSD6 antibody 17-beta-hydroxysteroid dehydrogenase type 6 antibody 3 hydroxysteroid epimerase antibody 3(alpha>beta) hydroxysteroid epimerase antibody 3(alpha>beta) hydroxysteroid epimerasel antibody 3-alpha->beta-HSE antibody 3-alpha->beta-hydroxysteroid epimerase antibody H17B6_HUMAN antibody HSD17B6 antibody HSE antibody Hydroxysteroid(17 beta) dehydrogenase 6 antibody Hydroxysteroid(17 beta) dehydrogenase 6 homolog(mouse) antibody Hydroxysteroid 17 beta dehydrogenase 6 antibody NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase antibody NAD+ dependent 3 alpha hydroxysteroid dehydrogenase antibody Oxidative 3 alpha hydroxysteroid dehydrogenase antibody Oxidative 3-alpha hydroxysteroid dehydrogenase antibody Oxidoreductase antibody Retinol dehydrogenase antibody RODH antibody SDR9C6 antibody Short chain dehydrogenase/reductase family 9C, member 6 antibody

O14756