Boster Immunoleader

antibody

Anti-HSD11B1 Antibody

PA1372-1

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section

Anti-HSD11B1 Antibody

PA1372-1

Polyclonal

Rabbit IgG polyclonal antibody for Corticosteroid 11-beta-dehydrogenase isozyme 1(HSD11B1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Concentration: 0.5-1μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human HSD11B1(16-33aa MAYYYYSANEEFRPEMLQ), different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. Tannin et al.(1991) localized the HSD11B1 gene to chromosome 1. The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe. Schutte et al.(2000) mapped the HSD11B1 gene to 1q32-q41.

1. "Entrez Gene: HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1".

HSD11B1

Corticosteroid 11-beta-dehydrogenase isozyme 1

hydroxysteroid(11-beta) dehydrogenase 1

11 beta HSD 1 antibody 11 beta HSD1 antibody 11 beta hydroxysteroid dehydrogenase 1 antibody 11 DH antibody 11-beta hydroxysteroid dehydrogenase, type 1 antibody 11-beta-HSD1 antibody 11-beta-hydroxysteroid dehydrogenase 1 antibody 11-DH antibody 11DH antibody Corticosteroid 11 beta dehydrogenase isozyme 1 antibody Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody CORTRD2 antibody DHI1_HUMAN antibody HDL antibody HSD 11 antibody HSD11 antibody HSD11B antibody HSD11B1 antibody HSD11L antibody Hydroxysteroid(11 beta) dehydrogenase 1 antibody Hydroxysteroid(11 beta) dehydrogenase antibody MGC13539 antibody SDR26C1 antibody short chain dehydrogenase/reductase family 26C, member 1 antibody

P28845