Anti-CD80 Antibody | Boster Immunoleader PA1365 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-CD80 Antibody

catalog :

PA1365

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-CD80 Antibody

Catalog Number :

PA1365

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for T-lymphocyte activation antigen CD80(CD80) detection. Tested with WB in Human.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human CD80(57-71aa EELAQTRIYWQKEKK).

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Cluster of Differentiation 80(also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28(for autoregulation and intercellular association) and CTLA-4(for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. The CD80 genes encode B7-1 which are structurally similar members of the immunoglobulin superfamily expressed on a variety of hematopoietic cell types. Reeves et al.(1997) stated that B7-1 and B7-2 provide a costimulatory signal to T cells by interacting with CD28 and CTLA4.

Reference :

1. Peach, R J; Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley P S (Sep. 1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". J. Biol. Chem. (UNITED STATES) 270 (36): 21181–7. 2. Stamper, C C; Zhang Y, Tobin J F, Erbe D V, Ikemizu S, Davis S J, Stahl M L, Seehra J, Somers W S, Mosyak L (Mar. 2001). "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses". Nature (England) 410 (6828): 608–11.

Gene Name :

CD80

Protein Name :

T-lymphocyte activation antigen CD80

Gene Full Name :

CD80 molecule

Synonyms :

Activation B7 1 antigen antibody Activation B7-1 antigen antibody Activation B71 antigen antibody B lymphocyte activation antigen B7 antibody B7 antibody B7-1 antibody B7-1 antigen antibody BB1 antibody CD 80 antibody CD28 antigen ligand 1 antibody CD28 antigen ligand 1 B7 1 antigen antibody CD28 antigen ligand 1 B71 antigen antibody CD28LG antibody CD28LG1 antibody CD80 antibody CD80 antigen antibody CD80 antigen precursor antibody CD80 molecule antibody CD80_HUMAN antibody Costimulatory factor CD80 antibody CTLA 4 counter receptor B7.1 antibody CTLA-4 counter-receptor B7.1 antibody LAB 7 antibody LAB7 antibody T lymphocyte activation antigen CD80 antibody T-lymphocyte activation antigen CD80 antibody

Uniprot ID :

P33681

more info or order :

Boster Immunoleader product webpage