Boster Immunoleader

antibody

Anti-Amyloid beta precursor protein Antibody

PA1362

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse

western blot, immunohistochemistry - paraffin section

Anti-Amyloid beta precursor protein Antibody

PA1362

Polyclonal

Rabbit IgG polyclonal antibody for Amyloid beta A4 protein(APP) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Concentration: 0.5-1μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human Amyloid beta precursor protein(18-32aa EVPTDGNAGLLAEPQ), identical to the related mouse and rat sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Amyloid precursor protein(APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates beta amyloid(Abeta), a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. APP undergoes posttranslational proteolytic processing by alpha-, beta-, and gamma-secretases. Alpha-secretase generates soluble amyloid protein, while beta- and gamma-secretases generate APP components with amyloidogenic features. These 2 processing pathways are mutually exclusive.

1. PDB 1RW6; Wang Y, Ha Y (August 2004). "The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain". Mol. Cell 15 (3): 343–53. 2. Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J (July 2006). "Synapse formation and function is modulated by the amyloid precursor protein". J. Neurosci. 26 (27): 7212–21. 3. Turner PR, O'Connor K, Tate WP, Abraham WC (May 2003). "Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory". Prog. Neurobiol. 70 (1): 1–32. 4. Duce JA et al. (2010). "Iron-Export Ferroxidase Activity of β- Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease". Cell 142 (6): 857–67.

APP

Amyloid beta A4 protein

amyloid beta(A4) precursor protein

A4 amyloid protein antibody A4 antibody A4_HUMAN antibody AAA antibody ABETA antibody ABPP antibody AD 1 antibody AD1 antibody AICD-50 antibody AICD-57 antibody AICD-59 antibody AID(50) antibody AID(57) antibody AID(59) antibody Alzheimer Disease 1 antibody Alzheimer disease amyloid protein antibody Alzheimer's Disease Amyloid Protein antibody Amyloid beta(A4) precursor protein antibody Amyloid beta A4 protein antibody Amyloid Beta A4 Protein Precursor Isoform A antibody Amyloid beta A4 protein precursor isoform b antibody Amyloid beta A4 protein precursor isoform c antibody Amyloid Beta Peptide antibody Amyloid beta protein antibody Amyloid intracellular domain 50 antibody Amyloid intracellular domain 57 antibody Amyloid intracellular domain 59 antibody Amyloid Of Aging And Alzheimer Disease antibody APP antibody APPI antibody Beta amyloid peptide antibody Beta-APP40 antibody Beta-APP42 antibody C31 antibody Cerebal Vascular Amyloid Peptide antibody Cerebral vascular amyloid peptide antibody CTFgamma antibody CVAP antibody Gamma-CTF(50) antibody Gamma-CTF(57) antibody Gamma-CTF(59) antibody Human mRNA For Amyloid A4 Precursor Of Alzheimer's Disease antibody Peptidase nexin II antibody peptidase nexin-II antibody PN 2 antibody PN II antibody PN-II antibody PN2 antibody PNII antibody PREA4 antibody Protease Nexin II antibody Protease nexin-II antibody S-APP-alpha antibody S-APP-beta antibody

P05067