Anti-Presenilin 2 Antibody | Boster Immunoleader PA1358 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Presenilin 2 Antibody

catalog :

PA1358

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

more info or order :

Boster Immunoleader product webpage

product information

Availability :

info changed 20150407

Product Name :

Anti-Presenilin 2 Antibody

Catalog Number :

PA1358

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Presenilin-2(PSEN2) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human Presenilin 2(39-51aa EDGENTAQWRSQE), different from the related mouse and rat sequences by two amino acids.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Kovacs et al.(1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments(endoplasmic reticulum and Golgi complex). Li et al.(1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.

Reference :

1. Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, Weber JL, Bird TD, Schellenberg GD (September 1995). "A familial Alzheimer's disease locus on chromosome 1". 2. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy".

Gene Name :

PSEN2

Protein Name :

Presenilin-2(PS-2)

Gene Full Name :

presenilin 2(Alzheimer disease 4)

Synonyms :

AD3L antibody AD3LP antibody AD4 antibody AD5 antibody Alzheimer disease 4 antibody CMD1V antibody E5-1 antibody OTTHUMP00000035671 antibody OTTHUMP00000035672 antibody OTTHUMP00000228286 antibody OTTHUMP00000228288 antibody Presenilin 2(Alzheimer disease 4) antibody Presenilin 2 antibody Presenilin-2 CTF subunit antibody PS-2 antibody PS2 antibody Psen2 antibody PSN2_HUMAN antibody PSNL2 antibody STM-2 antibody STM2 antibody

Uniprot ID :

P49810

more info or order :

Boster Immunoleader product webpage