Anti-LKB1 Antibody | Boster Immunoleader PA1355 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-LKB1 Antibody

catalog :

PA1355

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-LKB1 Antibody

Catalog Number :

PA1355

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase STK11(STK11) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Mouse, Rat

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human LKB1(421-433aa SSKIRRLSACKQQ), different from the mouse sequence by one amino acid.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11/LKB1 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor Smith et al.(1999) found that the mouse Lkb1 gene encodes a protein showing strong sequence similarity to human LKB1. Karuman et al.(2001) demonstrated that LKB1 physically associates with p53(191170) and regulates specific p53-dependent apoptosis pathways. Jenne et al.(1998) determined that the STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere direction. Smith et al.(1999) found that the mouse Lkb1 gene consists of 10 exons covering approximately 15 kb.

Reference :

1. Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Müller O, Back W, Zimmer M (January 1998). "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase".

Gene Name :

STK11

Protein Name :

Serine/threonine-protein kinase STK11

Gene Full Name :

serine/threonine kinase 11

Synonyms :

hLKB1 antibody Liver kinase B1 antibody LKB1 antibody PJS antibody Polarization related protein LKB1 antibody Renal carcinoma antigen NY-REN-19 antibody Serine/Threonine Kinase 11 antibody Serine/threonine protein kinase 11 antibody Serine/threonine protein kinase LKB1 antibody Serine/threonine protein kinase STK11 antibody Serine/threonine-protein kinase 11 antibody Serine/threonine-protein kinase LKB1 antibody Serine/threonine-protein kinase XEEK1 antibody Stk11 antibody STK11_HUMAN antibody

Uniprot ID :

Q15831

more info or order :

Boster Immunoleader product webpage