Boster Immunoleader

antibody

Anti-Muscarinic Acetylcholine Receptor 2 Antibody

PA1325-1

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section

info changed 20150427

Anti-Muscarinic Acetylcholine Receptor 2 Antibody

PA1325-1

Polyclonal

Rabbit IgG polyclonal antibody for Muscarinic acetylcholine receptor M2(CHRM2) detection. Tested with WB, IHC-P in Human; Mouse; Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, mouse, rat

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Concentration: 0.5-1μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

WB: The detection limit for CHRM2 is approximately 1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human Muscarinic Acetylcholine Receptor 2(356-370aa EKQNIVARKIVKMTK), identical to the related rat and mouse sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor. The M2 muscarinic receptors are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after stimulatory actions of the sympathetic nervous system, by slowing the speed of depolarization. The CHRM2 gene inhibits the release of acetylcholine from cholinergic fibers in the lungs and elsewhere. In airway parasympathetic neurons, it is decreased by viral infections and by interferon-gamma, increasing actylcholine release. This gene is though to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing. In a sample of 667 individuals from 304 families, Gosso MF et al. genotyped three single-nucleotide polymorphisms(SNPs) in the CHRM2 gene on 7q31-35. CHRM2 is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders. Wang et al. evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2(CHRM2) gene with alcohol dependence and major depressive syndrome.

1. Zhou, C., Fryer, A. D., Jacoby, D. B. Structure of the human M(2) muscarinic acetylcholine receptor gene and its promoter. Gene 271: 87-92, 2001. 2. Gosso MF, van Belzen M, de Geus EJ, et al. (2006). "Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families". Genes, Brain and Behavior 5 (8): 577–584. 3. Wang, J. C., Hinrichs, A. L., Stock, H., Budde, J., Allen, R., Bertelsen, S., Kwon, J. M., Wu, W., Dick, D. M., Rice, J., Jones, K., Nurnberger, J. I., Jr., and 10 others Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. Hum. Molec. Genet. 13: 1903-1911, 2004.

CHRM2

Muscarinic acetylcholine receptor M2

cholinergic receptor, muscarinic 2

7TM receptor antibody Acetylcholine receptor, muscarinic, 2 antibody Acm2 antibody ACM2_HUMAN antibody Cholinergic receptor muscarinic 2 antibody Cholinergic receptor, muscarinic 2, cardiac antibody Cholinergic receptor, muscarinic 2, isoform a antibody Cholinergic receptor, muscarinic 2a antibody CHRM 2 antibody CHRM2 antibody chrm2a antibody CM2 antibody FLJ43243 antibody HM 2 antibody HM2 antibody M2 antibody M2 muscarinic receptor antibody MGC120006 antibody MGC120007 antibody Muscarinic acetylcholine receptor M2 antibody Muscarinic M2 receptor antibody

P08172