Boster Immunoleader

antibody

Anti-CD82 Antibody

PA1307

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

info changed 20150507

Anti-CD82 Antibody

PA1307

Polyclonal

Rabbit IgG polyclonal antibody for CD82 antigen(CD82) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Liquid

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human CD82(253-267aa CRHVHSEDYSKVPKY), different from the related mouse and rat sequences by two amino acids.

Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4.

Immunogen affinity purified.

At -20˚C for one year, at 4˚C for one month. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

CD82(Cluster of Differentiation 82), also named KAI1, is a human protein encoded by the CD82 gene. The gene is mapped to 11p11.2. This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. The expression of CD82 protein appears to be correlated with lymph node metastasis in esophageal squamous cell carcinoma(ESCC). And the CD82 overexpression can suppress tumor invasiveness and metastatic potential by inducing MMP9 inactivation via upregulation of TIMP1.

1. Dong, J.-T.; Lamb, P. W.; Rinker-Schaeffer, C. W.; Vukanovic, J.; Ichikawa, T.; Isaacs, J. T.; Barrett, J. C. : KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 268: 884-886, 1995. 2. Mashimo, T.; Watabe, M.; Hirota, S.; Hosobe, S.; Miura, K.; Tegtmeyer, P. J.; Rinker-Shaeffer, C. W.; Watabe, K. : The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53. Proc. Nat. Acad. Sci. 95: 11307-11311, 1998. 3. Miyazaki, T.; Kato, H.; Shitara, Y.; Yoshikawa, M.; Tajima, K.; Masuda, N.; Shouji, H.; Tsukada, K.; Nakajima, T.; Kuwano, H. : Mutation and expression of the metastasis suppressor gene KAI1 in esophageal squamous cell carcinoma. Cancer 89: 955-962, 2000. 4. Jee, B. K.; Park, K. M.; Surendran, S.; Lee, W. K.; Han, C. W.; Kim, Y. S.; Lim, Y. : KAI1/CD82 suppresses tumor invasion by MMP9 inactivation via TIMP1 up-regulation in the H1299 human lung carcinoma cell line. Biochem. Biophys. Res. Commun. 342: 655-661, 2006.

CD82

CD82 antigen

CD82 molecule

4F9 antibody Antigen detected by monoclonal and antibody IA4 antibody C33 antibody C33 antigen antibody CD 82 antibody CD82 antibody Cd82 antibody CD82 antigen antibody CD82 molecule antibody CD82_HUMAN antibody GR 15 antibody GR15 antibody IA 4 antibody IA4 antibody Inducible membrane protein antibody Inducible membrane protein R2 antibody KAI 1 antibody KAI1 antibody Kangai 1(suppression of tumorigenicity 6, prostate; CD82 antigen(R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4) antibody Kangai 1 antibody Kangai1 antibody Metastasis suppressor Kangai 1 antibody Metastasis suppressor Kangai-1 antibody Metastasis suppressor Kangai1 antibody R2 antibody R2 leukocyte antigen antibody SAR 2 antibody SAR2 antibody ST 6 antibody ST6 antibody Suppression of tumorigenicity 6 antibody Suppression of tumorigenicity 6 prostate antibody Suppressor of tumorigenicity 6 antibody Suppressor of tumorigenicity 6 protein antibody Tetraspanin 27 antibody Tetraspanin-27 antibody Tetraspanin27 antibody Tspan 27 antibody Tspan-27 antibody Tspan27 antibody

P27701