Anti-SCN1B Antibody | Boster Immunoleader PA1244 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-SCN1B Antibody

catalog :

PA1244

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-SCN1B Antibody

Catalog Number :

PA1244

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Sodium channel subunit beta-1(SCN1B) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human SCN1B(72-94aa YENEVLQLEEDERFEGRVVWNGS), identical to the related rat and mouse sequences.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Voltage-gated sodium(Na+) channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. The complete coding region of Sodium channel, voltage-gated, beta 1(SCN1B) is found in approximately 9.0 kb of genomic DNA and consists of five exons(72 to 749 bp) and four introns(90 bp to 5.5 kb). It is mapped to 19q13.1 and can act as a candidate gene for hereditary disorders affecting membrane excitability. Sodium channel beta1 subunits play important roles in the regulation of sodium channel density and localization and are involved in axo-glial communication at nodes of Ranvier.

Reference :

1. Makita, N.; Sloan-Brown, K.; Weghuis, D. O.; Ropers, H. H.; George, A. L., Jr. : Genomic organization and chromosomal assignment of the human voltage-gated Na(+) channel beta-1 subunit gene (SCN1B). Genomics 23: 628-634, 1994. 2. Chen, C.; Westenbroek, R. E.; Xu, X.; Edwards, C. A.; Sorenson, D. R.; Chen, Y.; McEwen, D. P.; O'Malley, H. A.; Bharucha, V.; Meadows, L. S.; Knudsen, G. A.; Vilaythong, A.; Noebels, J. L.; Saunders, T. L.; Scheuer, T.; Shrager, P.; Catterall, W. A.; Isom, L. L. : Mice lacking sodium channel beta-1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J. Neurosci. 24: 4030-4042, 2004.

Gene Name :

SCN1B

Protein Name :

Sodium channel subunit beta-1

Gene Full Name :

sodium channel, voltage-gated, type I, beta subunit

Synonyms :

GEFSP1 antibody SCN1B antibody SCN1B_HUMAN antibody sodium channel beta 1 subunit antibody Sodium channel subunit beta 1 antibody Sodium channel subunit beta-1 antibody Sodium channel voltage gated type I beta antibody Sodium channel voltage gated type I beta subunit antibody

Uniprot ID :

Q07699

more info or order :

Boster Immunoleader product webpage