Boster Immunoleader

antibody

Anti-FGFR2 Antibody

PA1241

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section

Anti-FGFR2 Antibody

PA1241

Polyclonal

Rabbit IgG polyclonal antibody for Fibroblast growth factor receptor 2(FGFR2) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Concentration: 0.5-1μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human FGFR2(805-820aa EPCLPQYPHINGSVKT), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Fibroblast growth factor receptor 2(FGFR2) is a receptor for fibroblast growth factor encoded on a gene residing on chromosome 10. FGFR2 has also been designated as CD332. FGFR2 is a membrane-spanning tyrosine kinase that serves as a high affinity receptor for several members of the fibroblast growth factor(FGF) family. Its signals are absolutely required for vertebrate limb induction and that an FGFR2 signal is essential for the reciprocal regulation loop between FGF8 and FGF10 during limb induction. FGFR2 contributes to the outgrowth, differentiation, and maintenance of the inner cell mass and raise the possibility that this activity is mediated by FGF4 signals transmitted by FGFR2. The role of early FGF signaling in pregastrulation development as a possible adaptation to mammalian(amniote) embryogenesis is discussed.

1. Xu, X.; Weinstein, M.; Li, C.; Naski, M.; Cohen, R. I.; Ornitz, D. M.; Leder, P.; Deng, C. : Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 125: 753-765, 1998. 2. Arman, E.; Haffner-Krausz, R.; Chen, Y.; Heath, J. K.; Lonai, P. : Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc. Nat. Acad. Sci. 95: 5082-5087, 1998.

FGFR2

Fibroblast growth factor receptor 2(FGFR-2)

fibroblast growth factor receptor 2

bacteria-expressed kinase antibody BBDS antibody BEK antibody BEK fibroblast growth factor receptor antibody BFR1 antibody CD332 antibody CD332 antigen antibody CEK3 antibody CFD1 antibody Craniofacial dysostosis 1 antibody ECT1 antibody FGF receptor antibody FGFR 2 antibody FGFR-2 antibody Fgfr2 antibody FGFR2_HUMAN antibody Fibroblast growth factor receptor 2 antibody Hydroxyaryl protein kinase antibody Jackson Weiss syndrome antibody JWS antibody K SAM antibody K-sam antibody Keratinocyte growth factor receptor 2 antibody Keratinocyte growth factor receptor antibody KGFR antibody KSAM antibody protein tyrosine kinase, receptor like 14 antibody soluble FGFR4 variant 4 antibody TK14 antibody TK25 antibody

P21802