Anti-Cyclin D2 Antibody | Boster Immunoleader PA1225 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Cyclin D2 Antibody

catalog :

PA1225

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Cyclin D2 Antibody

Catalog Number :

PA1225

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for G1/S-specific cyclin-D2(CCND2) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human CCND2(46-60aa CVQKDIQPYMRRMVA), identical to the related rat and mouse sequences.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Cyclin D2, also known as CCND2, is a human gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1, Cyclin D2 and Cyclin D3 are the members of the cyclin family. Cyclin D2 mapped to 12p13, since the CCND1 gene is on 11q13, this may be another bit of evidence of the homology of chromosomes 11 and 12. Choi D et al proved the expression of pseudogene cyclin D2 mRNA in the human ovary increases with age, which may be a novel marker for decreased ovarian function associated with the aging process. And knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.

Reference :

1. Inaba, T.; Matsushime, H.; Valentine, M.; Roussel, M. F.; Sherr, C. J.; Look, A. T. : Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics 13: 565-574, 1992. 2. Choi D, Yoon S, Lee E, et al. (2001). "The expression of pseudogene cyclin D2 mRNA in the human ovary may be a novel marker for decreased ovarian function associated with the aging process.". J. Assist. Reprod. Genet. 18 (2): 110–3.

Gene Name :

CCND2

Protein Name :

G1/S-specific cyclin-D2

Gene Full Name :

cyclin D2

Synonyms :

CCND 2 antibody CCND2 antibody CCND2_HUMAN antibody CyclinD2 antibody G1/S specific cyclin D2 antibody G1/S-specific cyclin-D2 antibody KIAK0002 antibody MGC102758 antibody

Uniprot ID :

P30279

more info or order :

Boster Immunoleader product webpage