Anti-HRH3 Antibody | Boster Immunoleader PA1204 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-HRH3 Antibody

catalog :

PA1204

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-HRH3 Antibody

Catalog Number :

PA1204

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Histamine H3 receptor(HRH3) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human HRH3(428-445aa CPQKLKIQPHSSLEHCWK), different from the related rat sequence by three amino acids.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

The histamine receptor H3(HRH3) is a presynaptic autoreceptor on histamine neurons in the brain and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. The deduced 445-amino acid HRH3 protein contains 7 predicted transmembrane domains. And it shares 22% and 21.4% amino acid sequence homology with the H1(HRH1) and H2(HRH2) receptors, respectively. The expression of recombinant HRH3 in a variety of cell lines conferred an ability to inhibit adenylate cyclase in response to histamine, but not to acetylcholine or any other biogenic amine. Additionally, HRH3 was most notably observed throughout the thalamus, the ventromedial hypothalamus, and the caudate nucleus. Strong expression was also seen in layers II, V, and VIb of the cerebral cortex, in the pyramidal layers of the hippocampus, and in olfactory tubercle.

Reference :

1. Hill, S. J.; Ganellin, C. R.; Timmerman, H.; Schwartz, J. C.; Shankley, N. P.; Young, J. M.; Schunack, W.; Levi, R.; Haas, H. L. : International Union of Pharmacology. XIII. Classification of histamine receptors. Pharm. Rev. 49: 253-278, 1997.

Gene Name :

HRH3

Protein Name :

Histamine H3 receptor(H3R/HH3R)

Gene Full Name :

histamine receptor H3

Synonyms :

G protein coupled receptor 97 antibody G-protein coupled receptor 97 antibody GPCR 97 antibody GPCR97 antibody H3R antibody HH 3R antibody HH3 R antibody HH3R antibody Histamine H3 receptor antibody Histamine receptor H3 antibody HRH 3 antibody HRH3 antibody HRH3_HUMAN antibody OTTHUMP00000031459 antibody

Uniprot ID :

Q9Y5N1

more info or order :

Boster Immunoleader product webpage