Anti-Nicotinic Acetylcholine Receptor alpha 1 Antibody | Boster Immunoleader PA1203 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Nicotinic Acetylcholine Receptor alpha 1 Antibody

catalog :

PA1203

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Availability :

info changed 20140527

Product Name :

Anti-Nicotinic Acetylcholine Receptor alpha 1 Antibody

Catalog Number :

PA1203

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Acetylcholine receptor subunit alpha(CHRNA1) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human Nicotinic Acetylcholine Receptor alpha 1(22-36aa EHETRLVAKLFKDYS), identical to the related rat sequence, different from the related mouse sequence by one amino acid.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

CHRNA, also termed ACHRA, is mapped on 2q24-q32.This gene encodes the alpha subunit of the muscle acetylcholine receptor, which is the main target of pathogenic autoantibodies in autoimmune myasthenia gravis. The protein-coding sequence of the human alpha subu gene is divided into 9 exons that correspond to different structural and functional domains of the precursor molecule.

Reference :

1. Giraud, M.; Taubert, R.; Vandiedonck, C.; Ke, X.; Levi-Strauss, M.; Pagani, F.; Baralle, F. E.; Eymard, B.; Tranchant, C.; Gajdos, P.; Vincent, A.; Willcox, N.; Beeson, D.; Kyewski, B.; Garchon, H.-J. : An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature 448: 934-937, 2007. 2. Noda, M.; Furutani, Y.; Takahashi, H.; Toyosato, M.; Tanabe, T.; Shimizu, S.; Kikyotani, S.; Kayano, T.; Hirose, T.; Inayama, S.; Numa, S. : Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor. Nature 305: 818-823, 1983.

Gene Name :

CHRNA1

Protein Name :

Acetylcholine receptor subunit alpha

Gene Full Name :

cholinergic receptor, nicotinic, alpha 1(muscle)

Synonyms :

Acetylcholine receptor subunit alpha antibody ACHA_HUMAN antibody ACHRA antibody ACHRD antibody CHNRA antibody Cholinergic receptor nicotinic alpha polypeptide 1 antibody Cholinergic receptor, nicotinic, alpha polypeptide 1(muscle) antibody CHRNA antibody Chrna1 antibody CMS2A antibody FCCMS antibody Nicotinic cholinergic receptor alpha 1 antibody SCCMS antibody Schizophrenia neurophysiologic defect candidate antibody

Uniprot ID :

P02708

more info or order :

Boster Immunoleader product webpage