Anti-Caspase-2 Antibody | Boster Immunoleader PA1113 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Caspase-2 Antibody

catalog :

PA1113

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Caspase-2 Antibody

Catalog Number :

PA1113

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Caspase-2(CASP2) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human Caspase-2(417-439aa REGYAPGTEFHRCKEMSEYCSTL), identical to the related rat and mouse sequences.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.

Reference :

1. Bergeron, L.; Perez, G. I.; Macdonald, G.; Shi, L.; Sun, Y.; Jurisicova, A.; Varmuza, S.; Latham, K. E.; Flaws, J. A.; Salter, J. C. M.; Hara, H.; Moskowitz, M. A.; Li, E.; Greenberg, A.; Tilly, J. L.; Yuan, J. : Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev. 12: 1304-1314, 1998. 2. Tinel, A.; Tschopp, J. : The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 304: 843-846, 2004.

Gene Name :

CASP2

Protein Name :

Caspase-2(CASP-2)

Gene Full Name :

caspase 2, apoptosis-related cysteine peptidase

Synonyms :

Apoptosis related cysteine peptidase antibody CASP 2 antibody Casp 2L Pro antibody CASP-2 antibody CASP2 antibody CASP2_HUMAN antibody Caspase 2 apoptosis related cysteine protease antibody Caspase-2 subunit p12 antibody Caspase2 antibody Developmentally down regulated 2 antibody ICH 1 antibody ICH 1 protease antibody ICH 1L antibody ICH 1L/1S antibody ICH1 antibody ICH1 protease antibody ICH1L antibody ICH1L/1S antibody NEDD 2 antibody NEDD-2 antibody NEDD2 antibody NEDD2 apoptosis regulatory gene antibody Neural precursor cell expressed antibody Neural precursor cell expressed developmentally down regulated 2 antibody Neural precursor cell expressed developmentally down-regulated protein 2 antibody Protease ICH-1 antibody

Uniprot ID :

P42575

more info or order :

Boster Immunoleader product webpage