Anti-TIMP4 Antibody | Boster Immunoleader PA1078 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-TIMP4 Antibody

catalog :

PA1078

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

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product information

Availability :

info changed 20150507

Product Name :

Anti-TIMP4 Antibody

Catalog Number :

PA1078

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 4(TIMP4) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Liquid

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP4(208-224aa YRGHLPLRKEFVDIVQP), different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.

Contents :

Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4.

Purification :

Immunogen affinity purified.

Storage :

At -20˚C for one year, at 4˚C for one month. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

The tissue inhibitors of metalloproteinases(TIMPs) inhibit matrix metalloproteinases(MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP4 gene contains 5 exons that span 6 kb of genomic DNA. The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues. expressed TIMP4 inhibits MMPs in vitro. TIMP4 gene is mapped to chromosome 3p25. TIMP-4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2.

Reference :

1. Olson, T. M; Hirohata, S.; Ye, J.; Leco, K.; Seldin, M. F.; Apte, S. S. : Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 gene to human chromosome 3p25 and mouse chromosome 6, respectively. Genomics 51: 148-151, 1998. 2. Bigg, H. F.; Shi, Y. E.; Liu, Y. E.; Steffensen, B.; Overall, C. M. : Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. J. Biol. Chem. 272: 15496-15500, 1997.

Gene Name :

TIMP4

Protein Name :

Metalloproteinase inhibitor 4

Gene Full Name :

TIMP metallopeptidase inhibitor 4

Synonyms :

Metalloproteinase inhibitor 4 antibody TIMP 4 antibody TIMP metallopeptidase inhibitor 4 antibody TIMP-4 antibody Timp4 antibody TIMP4_HUMAN antibody Tissue inhibitor of metalloproteinase 4 antibody Tissue inhibitor of metalloproteinases 4 antibody

Uniprot ID :

Q99727

more info or order :

Boster Immunoleader product webpage