Anti-TIMP3 Antibody | Boster Immunoleader PA1077 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-TIMP3 Antibody

catalog :

PA1077

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, ELISA

publications citing this reagent :

Jia Z, Tian H, Kang K, Miao H, Liu K, Jiang S, et al. Expression of the tissue inhibitor of metalloproteinase-3 by transplanted VSMCs modifies heart structure and function after myocardial infarction. Transpl Immunol. 2014;30:149-58 pubmed publisher

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-TIMP3 Antibody

Catalog Number :

PA1077

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 3(TIMP3) detection. Tested with WB, ELISA in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human Predicted to work with: mouse, rat

Applications :

WB,ELISA

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

ELISA :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP3(198-211aa WAPPDKSIINATDP), different from the related rat and mouse sequences by one amino acid.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

The tissue inhibitors of metalloproteinases(TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy(SFD).

Reference :

1. Apte, S. S.; Mattei, M.-G.; Olsen, B. R. : Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22. Genomics 19: 86-90, 1994. 2. Stohr, H.; Roomp, K.; Felbor, U.; Weber, B. H. F. : Genomic organization of the human tissue inhibitor of metalloproteinases-3 (TIMP3). Genome Res. 5: 483-487, 1995.

Gene Name :

TIMP3

Protein Name :

Metalloproteinase inhibitor 3

Gene Full Name :

TIMP metallopeptidase inhibitor 3

Synonyms :

HSMRK222 antibody K222 antibody K222TA2 antibody Metalloproteinase inhibitor 3 antibody MIG 5 protein antibody MIG5 protein antibody Protein MIG 5 antibody Protein MIG-5 antibody SFD antibody Sorsby fundus dystrophy pseudoinflammatory antibody TIMP 3 antibody TIMP metallopeptidase inhibitor 3 antibody TIMP-3 antibody TIMP3 antibody TIMP3_HUMAN antibody Tissue Inhibitor of Metalloproteinase 3 antibody Tissue inhibitor of metalloproteinases 3 antibody Tissue inhibitor of metalloproteinases3 antibody

Uniprot ID :

P35625

more info or order :

Boster Immunoleader product webpage