Anti-KCNN4 Antibody | Boster Immunoleader PA1047-1 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-KCNN4 Antibody

catalog :

PA1047-1

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-KCNN4 Antibody

Catalog Number :

PA1047-1

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Intermediate conductance calcium-activated potassium channel protein 4(KCNN4) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human KCNN4(14-29aa RRKRLLEQEKSLAGWA), different from the related mouse and rat sequences by two amino acids.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Intermediate conductance calcium-activated potassium channel protein 1(KCNN4, Kca3.1) is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. KCNN4 may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

Reference :

1. Joiner WJ, Wang LY, Tang MD, Kaczmarek LK. Joiner,W.J., Wang,L.Y., Tang,M.D. and Kaczmarek,L.K. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proc. Natl. Acad. Sci. U.S.A.1997; 94 (20), 11013-11018. 2. Hoffman JF, Joiner W, Nehrke K, Potapova O, Foye K, Wickrema A. The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. Proc. Natl. Acad. Sci. U.S.A.2003; 100 (12), 7366-7371. 3. Jones HM, Hamilton KL, Papworth GD, Syme CA, Watkins SC, Bradbury NA, Devor DC. Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1. J. Biol. Chem.2004; 279 (15), 15531-15540.

Gene Name :

KCNN4

Protein Name :

Intermediate conductance calcium-activated potassium channel protein 4

Gene Full Name :

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

Synonyms :

hIKCa1 antibody hKCa4 antibody hSK4 antibody IK1 antibody IKCa1 antibody Intermediate conductance calcium activated potassium channel protein 4 antibody Intermediate conductance calcium-activated potassium channel protein 4 antibody KCa3.1 antibody KCa4 antibody KCNN 4 antibody Kcnn4 antibody KCNN4_HUMAN antibody Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4 antibody Putative Gardos channel antibody SK4 antibody SKCa 4 antibody SKCa4 antibody

Uniprot ID :

O15554

more info or order :

Boster Immunoleader product webpage