Anti-CXCR2 Antibody | Boster Immunoleader PA1029 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-CXCR2 Antibody

catalog :

PA1029

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

publications citing this reagent :

Cao D, Zhang Z, Xie R, Jiang B, Ji R, Gao Y. Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2. Exp Neurol. 2014;261:328-36 pubmed publisher
Xu J, Zhu M, Zhang X, Tian H, Zhang J, Wu X, et al. NFκB-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice. J Neuroinflammation. 2014;11:38 pubmed publisher
Zhang Z, Cao D, Zhang X, Ji R, Gao Y. Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons. Pain. 2013;154:2185-97 pubmed publisher

more info or order :

Boster Immunoleader product webpage

product information

Availability :

info changed 20141219

Product Name :

Anti-CXCR2 Antibody

Catalog Number :

PA1029

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 2(CXCR2) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence in the middle region of human CXCR2(196-212aa CYEDMGNNTANWRMLLR), different from the related mouse sequence by six amino acids.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family(subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.

Reference :

1. Murphy P.M., Tiffany H.L.;"Cloning of complementary DNA encoding a functional human interleukin-8 receptor."; Science 253:1280-1283(1991). 2. Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P., Beckmann M.P.; "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2."; Mol. Immunol. 30:359-367(1993). 3. Sprenger H., Lloyd A.R., Lautens L.L., Bonner T.I., Kelvin D.J.;"Structure, genomic organization, and expression of the human interleukin-8 receptor B gene.";J. Biol. Chem. 269:11065-11072(1994).

Gene Name :

CXCR2

Protein Name :

C-X-C chemokine receptor type 2(CXC-R2/CXCR-2)

Gene Full Name :

chemokine(C-X-C motif) receptor 2

Synonyms :

C-X-C chemokine receptor type 2 antibody CD 182 antibody CD182 antibody CD182 antigen antibody CDw128b antibody Chemokine(CXC) receptor 2 antibody CMKAR2 antibody CXC-R2 antibody CXCR 2 antibody CXCR-2 antibody CXCR2 antibody CXCR2_HUMAN antibody GRO/MGSA receptor antibody High affinity interleukin-8 receptor B antibody IL 8 receptor type 2 antibody IL 8R B antibody IL-8 receptor type 2 antibody IL-8R B antibody IL8 RB antibody IL8 receptor type 2 antibody IL8R B antibody IL8R2 antibody IL8RA antibody Interleukin 8 Receptor B antibody

Uniprot ID :

P25025

more info or order :

Boster Immunoleader product webpage