Boster Immunoleader

antibody

Anti-COX1/Cyclooxygenase 1 Antibody

PA1027

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section

Anti-COX1/Cyclooxygenase 1 Antibody

PA1027

Polyclonal

Rabbit IgG polyclonal antibody for Prostaglandin G/H synthase 1(PTGS1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Concentration: 0.5-1μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human COX1(35-52aa CCYYPCQHQGICVRFGLD), different from the related rat and mouse sequences by two amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Cyclooxygenase 1(COX1), also known as Prostaglandin-endoperoxide synthase(PTGS1) or mitochondrial cytochrome c oxidase subunit 1, is the key enzyme in prostaglandin biosynthesis. The gene was approximately 40 kb long, with 11 protein-coding exons. There were 599 amino acid residues with a calculated molecular mass of approximately 68 kD. By analysis of a human/hamster somatic hybrid DNA panel, Funk et al.(1991) demonstrated that the PTGS1 gene maps to chromosome 9. Human prostaglandin endoperoxide synthase exhibited 91% amino acid identity with the sheep enzyme. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

1. Yokoyama, C.; Tanabe, T. : Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochem. Biophys. Res. Commun. 165: 888-894, 1989. 2. Langenbach, R.; Morham, S. G.; Tiano, H. F.; Loftin, C. D.; Ghanayem, B. I.; Chulada, P. C.; Mahler, J. F.; Lee, C. A.; Goulding, E. H.; Kluckman, K. D.; Kim, H. S.; Smithies, O. : Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 83: 483-492, 1995.

PTGS1

Prostaglandin G/H synthase 1

prostaglandin-endoperoxide synthase 1(prostaglandin G/H synthase and cyclooxygenase)

COX 1 antibody COX 3 antibody COX-1 antibody COX1 antibody COX3 antibody Cyclooxygenase 1 antibody Cyclooxygenase 3, included antibody Cyclooxygenase-1 antibody Cyclooxygenase1 antibody EC 1.14.99.1 antibody Partial COX1 proteins, included antibody PCOX 1 antibody PCOX1 antibody PGG/HS antibody PGH synthase 1 antibody PGH1_HUMAN antibody PGHS 1 antibody PGHS-1 antibody PGHS1 antibody PHS 1 antibody PHS1 antibody Prostaglandin endoperoxide synthase 1 antibody Prostaglandin G/H synthase 1 antibody Prostaglandin G/H synthase and cyclooxygenase antibody Prostaglandin H Synthase 1 antibody Prostaglandin H2 synthase 1 antibody Prostaglandin-endoperoxide synthase 1(prostaglandin G/H synthase and cyclooxygenase) antibody Prostaglandin-endoperoxide synthase 1 antibody PTGHS antibody PTGS 1 antibody PTGS1 antibody

P23219