Anti-Bax Antibody | Boster Immunoleader PA1013 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Bax Antibody

catalog :

PA1013

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

publications citing this reagent :

Han N, Yu L, Song Z, Luo L, Wu Y. Agmatine protects Müller cells from high‑concentration glucose‑induced cell damage via N‑methyl‑D‑aspartic acid receptor inhibition. Mol Med Rep. 2015;12:1098-106 pubmed publisher
Li T, Zhang J, Fei S, Zhu S, Zhu J, Qiao X, et al. Glutamate microinjection into the hypothalamic paraventricular nucleus attenuates ulcerative colitis in rats. Acta Pharmacol Sin. 2014;35:185-94 pubmed publisher
Zhou Y, Qiu Y, Xu L, Guo J, Li L. Xiao-Chai-Hu Tang in treating model mice with D-galactosamine-induced liver injury. Afr J Tradit Complement Altern Med. 2012;9:405-11 pubmed
Zhou Y, Tan X, Kuang W, Liu L, Wan L. Erythromycin ameliorates cigarette-smoke-induced emphysema and inflammation in rats. Transl Res. 2012;159:464-72 pubmed publisher
Zhen-Qiang F, Bing-Wei Y, Yong-Liang L, Xiang-Wei W, Shan-Hong Y, Yuan-Ning Z, et al. Localized expression of human BMP-7 by BM-MSCs enhances renal repair in an in vivo model of ischemia-reperfusion injury. Genes Cells. 2012;17:53-64 pubmed publisher
Xu Y, Feng L, Wang S, Zhu Q, Lin J, Lou C, et al. Phytoestrogen calycosin-7-O-β-D-glucopyranoside ameliorates advanced glycation end products-induced HUVEC damage. J Cell Biochem. 2011;112:2953-65 pubmed publisher

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Bax Antibody

Catalog Number :

PA1013

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Apoptosis regulator BAX(BAX) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human Bax(68-81aa DELDSNMELQRMIA), different form the related rat and mouse sequences by one amino acid.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

BAX(Bcl-2 Associated X Protein) is a member of the Bcl-2 gene family, it encodes a 21-kDa protein whose association with Bcl-2 is believed to play a critical role in regulating apoptosis. Human BAX gene is located in the q13.3-q13.4 region of human chromosome 19. Bax is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases. It resides in an inactive state in the cytosol of many cells. Bax consists of 9 alpha helices and has extensive amino acid homology with Bcl-2, focused within highly conserved domains I and II. Bax is encoded by six exons and demonstrates a complex pattern of alternative RNA splicing that predicts a 21 kd membrane(alpha) and two forms of cytosolic protein(beta and gamma). BAX and BAK are essential for regulating the number of B cells at both immature and mature developmental stages. They are critical mediators of B cell death induced by multiple stimuli.

Reference :

1. Apte, S. S.; Mattei, M.-G.; Olsen, B. R. : Mapping of human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX-delta. Genomics 26: 592-594, 1995. 2. Guo, B.; Zhai, D.; Cabezas, E.; Welsh, K.; Nouraini, S.; Satterthwait, A. C.; Reed, J. C. : Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature 423: 456-461, 2003. 3. Oltvai, Z. N.; Milliman, C. L.; Korsmeyer, S. J. : Bcl-2 heterodimers in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619, 1993. 4. Takeuchi, O.; Fisher, J.; Suh, H.; Harada, H.; Malynn, B. A.; Korsmeyer, S. J. : Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc. Nat. Acad. Sci. 102: 11272-11277, 2005.

Gene Name :

BAX

Protein Name :

Apoptosis regulator BAX

Gene Full Name :

BCL2-associated X protein

Synonyms :

apoptosis regulator BAX antibody Apoptosis regulator BAX cytoplasmic isoform beta antibody Apoptosis regulator BAX membrane isoform alpha antibody BAX antibody Bax isoform psi antibody BAX protein cytoplasmic isoform delta antibody Bax protein cytoplasmic isoform delta. antibody Bax protein cytoplasmic isoform gamma antibody Bax zeta antibody Bax-protein antibody BAX_HUMAN antibody Bcl-2-like protein 4 antibody BCL2 associated X protein antibody BCL2 associated X protein omega antibody BCL2 associated X protein transcript variant delta2 antibody Bcl2-L-4 antibody, BCL2L4 antibody

Uniprot ID :

Q07812

more info or order :

Boster Immunoleader product webpage