Anti-beta-Amyloid Protein Antibody (monoclonal) | Boster Immunoleader MA1109 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-beta-Amyloid Protein Antibody (monoclonal)

catalog :

MA1109

quantity :

100 ug/vial

price :

200 USD

clonality :

monoclonal

host :

mouse

application :

immunohistochemistry - paraffin section

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-beta-Amyloid Protein Antibody (monoclonal)

Catalog Number :

MA1109

Clonality :

Monoclonal (Clone: AP-5)

Description short :

Mouse IgG monoclonal antibody for beta-Amyloid Protein detection. Tested with IHC-P in Human. No cross reactivity with other proteins.

Price :

200 USD

Ig type :

Mouse IgG1

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Human

Applications :

IHC-P

Immunohistochemistry(Paraffin-embedded S ... :

At 0.5-1μg/ml to detect β-amyloid protein in formalin fixed and paraffin embedded tissues.

Notes :

Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

Synthetic beta-amyloid peptide(1-40), conjugated to KLH.

Contents :

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

Purification :

Ascites

Reconstitution :

1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by SA1021 in IHC(P).

Background :

Beta amyloid protein is 4.2-kD polypeptide. Glenner and Wong(1984) purified a protein derived from the twisted beta-pleated sheet fibrils present in cerebrovascular amyloidoses and in the amyloid plaques associated with Alzheimer disease. The proteins from both disorders have an identical 28-amino acid sequence. memory deficits in middle-aged Tg2576 mice are caused by the extracellular accumulation of a 56-kDa soluble amyloid-beta assembly. Amyloid beta protein(Abeta) deposition in the brain is a hallmark of Alzheimer's disease(AD).

Reference :

1. Lesne, S.; Koh, M. T.; Kotilinek, L.; Kayed, R.; Glabe, C. G.; Yang, A.; Gallagher, M.; Ashe, K. H. : A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440: 352-357, 2006. 2. Lorenzo, A.; Yuan, M.; Zhang, Z.; Paganetti, P. A.; Sturchler-Pierrat, C.; Staufenbiel, M.; Mautino, J.; Vigo, F. S.; Sommer, B.; Yankner, B. A. : Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nature Neurosci. 3: 460-464, 2000.

Gene Name :

APP

Protein Name :

Amyloid beta A4 protein

Gene Full Name :

amyloid beta (A4) precursor protein

Uniprot ID :

Human(P05067), Mouse(P12023), Rat(P08592)

more info or order :

Boster Immunoleader product webpage