Boster Immunoleader

ELISA/assay

Mouse Hemojuvelin PicoKine ELISA Kit

EK1370

1 x96 well plate

369 USD

Mouse Hemojuvelin PicoKine ELISA Kit

EK1370

369 USD

Sandwich ELISA kit for Quantitative Detection of Mouse Hemojuvelin

NSO, Q33-D393

1 x96 well plate

156pg/ml-10,000pg/ml

<10pg/ml

Sample 1: n=16; Mean(ng/ml): 1.43; Standard deviation: 0.073; CV(%): 5.1 Sample 2: n=16; Mean(ng/ml): 3.06; Standard deviation: 0.113; CV(%): 3.7 Sample 3: n=16; Mean(ng/ml): 5.72; Standard deviation: 0.223; CV(%): 3.9

Sample 1: n=24; Mean(ng/ml): 1.46; Standard deviation: 0.11; CV(%): 7.5 Sample 2: n=24; Mean(ng/ml): 3.24; Standard deviation: 0.237; CV(%): 7.3 Sample 3: n=24; Mean(ng/ml): 5.91; Standard deviation: 0.402; CV(%): 6.8

There is no detectable cross-reactivity with other relevant proteins.

Store at 4˚C for 6 months, at -20˚C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

This kit is used for quantitative detection of mouse Hemojuvelin in cell culture supernates, serum and plasma(heparin, EDTA).

Mouse

Catalog number Description Quantity - 96-well plate precoated with anti- mouse Hemojuvelin antibody 1 ST0000-10 Lyophilized mouse Hemojuvelin standard 10ng/tube×2 AR1107 Biotinylated anti- mouse Hemojuvelin antibody 130μl(dilution 1:100) AR1103 Avidin-Biotin-Peroxidase Complex (ABC) 130μl(dilution 1:100) AR1106-1 Sample diluent buffer 30 ml AR1106-2 Antibody diluent buffer 12ml AR1106-3 ABC diluent buffer 12ml AR1104 TMB color developing agent 10ml AR1105 TMB stop solution 10ml

Hemojuvelin (HJV/RGMc/HFE2) is a membrane-bound and soluble protein in mammals. It is a member of a three gene family (in vertebrates) called the repulsive guidance molecules. In mouse, the Hemojuvelin protein is encoded by the HFE2 gene, and it is mapped to Chromosome 3. It was concluded that downregulation of hepatic Hemojuvelin during inflammation may induce a temporary elimination of iron sensing. Hemojuvelin is a coreceptor for bone morphogenetic proteins (BMPs), and inhibition of endogenous BMP signaling reduces hepcidin expression and increases serum iron in mice. Furthermore, Hemojuvelin may play inhibitory roles in prostate cancer by suppressing cell growth, adhesion, migration and invasion.

HFE2

Hemojuvelin

hemochromatosis type 2 (juvenile)

2310035L15Rik 5230400G09Rik AI414844 AI789733 DL M Haemojuvelin HEMOCHROMATOSIS HEMOCHROMATOSIS DUE TO DEFECT IN HEMOJUVELIN HEMOCHROMATOSIS DUE TO DEFECT IN HEPCIDIN ANTIMICROBIAL PEPTIDE HEMOCHROMATOSIS JUVENILE Hemochromatosis type 2 (juvenile) Hemochromatosis type 2 Hemochromatosis type 2 protein Hemochromatosis type 2 protein homolog HEMOCHROMATOSIS, TYPE 2A HEMOCHROMATOSIS, TYPE 2B Hemojuvelin HFE 2 Hfe2 HFE2A HJV JH Juvenile MGC23953 OTTHUMP00000059680 Repulsive guidance molecule c RGM C RGM domain family member C RGMC

Q7TQ32