Boster Immunoleader

ELISA/assay

Mouse RANK PicoKine ELISA Kit

EK0830

1 x96 well plate

420 USD

Mouse RANK PicoKine ELISA Kit

EK0830

420 USD

Sandwich ELISA kit for Quantitative Detection of Mouse RANK

NSO, Q30-P213

1 x96 well plate

62.5pg/ml-4000pg/ml

<2pg/ml

Sample 1: n=16; Mean(pg/ml): 735; Standard deviation: 38.22; CV(%): 5.2 Sample 2: n=16; Mean(pg/ml): 1428; Standard deviation: 87.11; CV(%): 6.1 Sample 3: n=16; Mean(pg/ml): 2873; Standard deviation: 140.8; CV(%): 4.9

Sample 1: n=24; Mean(pg/ml): 873; Standard deviation: 57.62; CV(%): 6.6 Sample 2: n=24; Mean(pg/ml): 1740; Standard deviation: 125.28; CV(%): 7.2 Sample 3: n=24; Mean(pg/ml): 3226; Standard deviation: 170.98; CV(%): 5.3

There is no detectable cross-reactivity with other relevant proteins.

Store at 4˚C for 6 months, at -20˚C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

This kit is used for quantitative detection of mouse RANK in cell culture supernates and serum.

Mouse

Catalog number Description Quantity - 96-well plate precoated with anti- mouse RANK antibody 1 ST0000-10 Lyophilized recombinant mouse RANK standard 10ng/tubex2 AR1107 Biotinylated anti- mouse RANK antibody 130ul(dilution 1:100) AR1103 Avidin-Biotin-Peroxidase Complex(ABC) 130ul(dilution 1:100) AR1106-1 Sample diluent buffer 30ml AR1106-2 Antibody diluent buffer 12ml AR1106-3 ABC diluent buffer 12ml AR1104 TMB color developing agent 10ml AR1105 TMB stop solution 10ml

Receptor Activator of Nuclear Factor kappa B(RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and differentiation of osteoclasts. RANK contains 383 amino acids in its intracellular domain(residues 234-616), which contain three putative TRAF-binding domains(termed I, II, and III). RANK interacts with various TRAFs through distinct motifs and activates NF-kappaB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kappaB activation, whereas RANK most likely activates JNK through a TRAF2-interacting region in RANK.

TNFRSF11A

Tumor necrosis factor receptor superfamily member 11A

tumor necrosis factor receptor superfamily, member 11a, NFKB activator

CD265 FEO LOH18CR1 Loss of heterozygosity 18 chromosomal region 1 ODFR OFE OPTB7 Osteoclast differentiation factor receptor OSTS PDB2 Receptor activator of NF-KB Receptor activator of nuclear factor kappa B TNFRSF11A TNR11_HUMAN TRANCER Tumor necrosis factor receptor superfamily member 11A Tumor necrosis factor receptor superfamily member 11a activator of NFKB Tumor necrosis factor receptor superfamily member 11a NFKB activator

O35305