Boster Immunoleader

ELISA/assay

Mouse IL-1 beta PicoKine ELISA Kit

EK0394

1 x96 well plate

420 USD

Mouse IL-1 beta PicoKine ELISA Kit

EK0394

420 USD

Sandwich ELISA kit for Quantitative Detection of Mouse IL-1 beta

E.coli,V118-S269

1 x96 well plate

12.5pg/ml-800pg/ml

<1pg/ml

Sample 1: n=16; Mean(pg/ml): 86; Standard deviation: 6.97; CV(%): 8.1 Sample 2: n=16; Mean(pg/ml): 376; Standard deviation: 19.55; CV(%): 5.2 Sample 3: n=16; Mean(pg/ml): 587; Standard deviation: 24.07; CV(%): 4.1

Sample 1: n=24; Mean(pg/ml): 79; Standard deviation: 7.03; CV(%): 8.9 Sample 2: n=24; Mean(pg/ml): 346; Standard deviation: 25.6; CV(%): 7.4 Sample 3: n=24; Mean(pg/ml): 558; Standard deviation: 37.94; CV(%): 6.8

There is no detectable cross-reactivity with other relevant proteins.

Store at 4˚C for 6 months, at -20˚C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

This kit is used for quantitative detection of mouse IL-1 beta in cell culture supernates, serum and plasma(heparin, EDTA).

Mouse

Catalog number Description Quantity - 96-well plate precoated with anti- mouse IL-1 beta antibody 1 ST0000-10 Lyophilized recombinant mouse IL-1 beta standard 10ng/tubex2 AR1107 Biotinylated anti- mouse IL-1 beta antibody 130ul(dilution 1:100) AR1103 Avidin-Biotin-Peroxidase Complex(ABC) 130ul(dilution 1:100) AR1106-1 Sample diluent buffer 30ml AR1106-2 Antibody diluent buffer 12ml AR1106-3 ABC diluent buffer 12ml AR1104 TMB color developing agent 10ml AR1105 TMB stop solution 10ml

Interleukin-1beta(IL-1beta) is a potent stimulator of bone resorption whose gene is mapped to 2q14, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1beta, a prominent microglia-derived cytokine, caused oligodendrocyte death in coculture with astrocytes and microglia, but not in pure culture of oligodendrocytes alone1. It also can cause nuclear export of a specific NCOR corepressor complex, resulting in derepression of a specific subset of nuclear factor-kappa-B(NFKB)-regulated genes2. Furthermore, Microenvironmental IL-1beta and, to a lesser extent, IL-1alpha are required for in vivo angiogenesis and invasiveness of different tumor cells3. Additional, the cooperation of IL-1beta and PDGFB induces contractile-to-synthetic phenotype modulation of human aortic smooth muscle cells in culture4. Moreover, the association with disease may be explained by the biologic properties of IL-1beta, which is an important proinflammatory cytokine and a powerful inhibitor of gastric acid secretion.

IL1B

Interleukin-1 beta

interleukin 1, beta

Catabolin Hematopoietin 1 IFN beta inducing factor IL 1 IL 1 beta IL 1B IL-1 beta IL1 IL1 BETA IL1B IL1B_HUMAN IL1F2 Interleukin 1 beta Interleukin 1 beta precursor Interleukin-1 beta LAF OAF Osteoclast activating factor Preinterleukin beta Pro interleukin 1 beta

P10749