Boster Immunoleader

ELISA/assay

Human IL-1 beta PicoKine ELISA Kit

EK0392

1 x96 well plate

260 USD

Human IL-1 beta PicoKine ELISA Kit

EK0392

260 USD

Sandwich ELISA kit for Quantitative Detection of Human IL-1 beta

E.coli,A117-S269

1 x96 well plate

3.9pg/ml-250pg/ml

<0.15pg/ml

Sample 1: n=16; Mean(pg/ml): 19; Standard deviation: 1.0; CV(%): 5.3 Sample 2: n=16; Mean(pg/ml): 41.2; Standard deviation: 2.6; CV(%): 6.3 Sample 3: n=16; Mean(pg/ml): 116; Standard deviation: 6.5; CV(%): 5.6

Sample 1: n=24; Mean(pg/ml): 27.5; Standard deviation: 1.6; CV(%): 5.8 Sample 2: n=24; Mean(pg/ml): 61.3; Standard deviation: 4.1; CV(%): 6.7 Sample 3: n=24; Mean(pg/ml): 179.1; Standard deviation: 12.7; CV(%): 7.1

There is no detectable cross-reactivity with other relevant proteins.

Store at 4˚C for 6 months, at -20˚C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

This kit is used for quantitative detection of human IL-1 beta in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Human

Catalog number Description Quantity - 96-well plate precoated with anti- human IL-1 beta antibody 1 ST0000-1 Lyophilized recombinant human IL-1 beta standard 1ng/tubex2 AR1107 Biotinylated anti- human IL-1 beta antibody 130ul(dilution 1:100) AR1103 Avidin-Biotin-Peroxidase Complex(ABC) 130ul(dilution 1:100) AR1106-1 Sample diluent buffer 30ml AR1106-2 Antibody diluent buffer 12ml AR1106-3 ABC diluent buffer 12ml AR1104 TMB color developing agent 10ml AR1105 TMB stop solution 10ml

Interleukin-1beta(IL-1beta) is a potent stimulator of bone resorption whose gene is mapped to 2q14, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1beta, a prominent microglia-derived cytokine, caused oligodendrocyte death in coculture with astrocytes and microglia, but not in pure culture of oligodendrocytes alone. It also can cause nuclear export of a specific NCOR corepressor complex, resulting in derepression of a specific subset of nuclear factor-kappa-B(NFKB)-regulated genes. Furthermore, Microenvironmental IL-1beta and, to a lesser extent, IL-1alpha are required for in vivo angiogenesis and invasiveness of different tumor cells. Additional, the cooperation of IL-1beta and PDGFB induces contractile-to-synthetic phenotype modulation of human aortic smooth muscle cells in culture. Moreover, the association with disease may be explained by the biologic properties of IL-1beta, which is an important proinflammatory cytokine and a powerful inhibitor of gastric acid secretion.

IL1B

Interleukin-1 beta

interleukin 1, beta

Catabolin Hematopoietin 1 IFN beta inducing factor IL 1 IL 1 beta IL 1B IL-1 beta IL1 IL1 BETA IL1B IL1B_HUMAN IL1F2 Interleukin 1 beta Interleukin 1 beta precursor Interleukin-1 beta LAF OAF Osteoclast activating factor Preinterleukin beta Pro interleukin 1 beta

P01584