protein

Biotinylated Human BTN2A2 (C-Fc-Avi)

CY56

20 ug;100 ug

302 USD

Biotinylated Human BTN2A2 (C-Fc-Avi)

protein

Q8WVV5

20 ug;100 ug

302 USD

CY56-20ug

20ug;100ug

Biotinylated Recombinant Human Butyrophilin Subfamily 2 Member A2 is produced by our Mammalian expression system and the target gene encoding Gln33-Val237 is expressed with a Fc, Avi tag at the C-terminus.

Human Cells

Butyrophilin 2A2 (BTN2A2) is a widely expressed type I transmembrane glycoprotein that functions as a negative regulator of immune responses. Mature human Butyrophilin 2A2 consisits of a 233 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 237 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A2 that lack the first, second, or both Iglike domains as well as isoforms with substitutions and deletions in the cytoplasmic region. Within the immune system, Butyrophilin 2A2 is expressed on thymic epithelial cells, naïve B cells, splenic NK cells, dendritic cells, and peritoneal macrophages and is up-regulated with cell activation. Butyrophilin 2A2 inhibits T cell proliferation and activation and enhances the development of FoxP3+ regulatory T cells. Its up-regulation in the hippocampus is associated with schizophrenia.

Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Ambient

Butyrophilin subfamily 2 member A2; BTN2A2