protein

Biotinylated Human Mesothelin (C-6His-Avi)

CY05

20 ug;100 ug

Biotinylated Human Mesothelin (C-6His-Avi)

protein

AAH09272.1

20 ug;100 ug

288

CY05-20ug

20ug;100ug

Biotinylated Recombinant Human Mesothelin is produced by our Mammalian expression system and thetarget gene encoding Glu296-Ser598 is expressed with a 6His, Avi tag at the C-terminus.

Human Cells

Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura, pericardium, and peritoneum) and epithelial cells of the trachea, tonsils, fallopian tube, and kidneys. Mesothelin plays an important role in cell survival, proliferation, migration, invasion, tumor progression, and resistance to chemotherapy. The overexpression of mesothelin can activate NF-κB and signal transducer and activator of transcription 3 (Stat3), inhibit apoptotic signaling and TNF-α-induced apoptosis, and accelerate the G1–S transition. Mesothelin is also found overexpressed in various cancers, including malignant mesothelioma, pancreatic or ovarian carcinoma, sarcomas and in some gastrointestinal or pulmonary carcinomas. As a result of its limited expression in normal tissues, mesothelin has been reported as an ideal tumor-associated marker for the development of targeted therapy.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Ambient

Megakaryocyte potentiating factor; mesothelin; Pre-pro-megakaryocyte-potentiating factor; soluble MPF mesothelin related protein; CAK1; MPF; MSLN;SMR; CAK1; CAK1 antigen