protein

Recombinant Human Tissue-Type Plasminogen Activator/PLAT (C-6His)

CX67

10 ug;50 ug;500 ug;1 mg

Recombinant Protein

Recombinant Human Tissue-Type Plasminogen Activator/PLAT (C-6His)

Recombinant Proteins

CX67-10ug

10 ug;50 ug;500 ug;1 mg

P00750

Tissue-type plasminogen activator (PLAT) is a protein that secreted into extracellular space. PLAT contains five domains: EGF-like domain, fibronectin type-I domain, 2 kringle domains and peptidase S1 domain. It belongs to the peptidase S1 family. The main function of this protein is to convert plasminogen into biologically active plasmin. As a protease, PLAT plays a crucial role in regulating blood fibrinolysis, maintaining the homeostasis of extracellular matrix and in modulating the post-translational activation of growth factors. PLAT is found not only in the blood, where its primary function is as a thrombolytic enzyme, but also in the central nervous system (CNS). It participates in a number of physiological and pathological events in the CNS, as well as the role of neuroserpin as the natural regulator of PLAT's activity in these processes. Increased or decreased activity of PLAT leads to hyperfibrinolysis or hypofibrinolysis, respectively. In addition, as a cytokine, PLAT plays a pivotal role in the pathogenesis of renal interstitial fibrosis through diverse mechanisms. Thus, as a fibrogenic cytokine, it promotes the progression of kidney diseases.

Human Cells

Ambient

Lyophilized from a 0.2 μm filtered solution of 20mM MES,150mM NaCl,0.2mM GaCl2,pH5.5.

T-PA, TPA, t-plasminogen activator, Tissue plasminogen activator,