product summary
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company name :
Bon Opus Biosciences
product type :
protein
product name :
Recombinant Cynomolgus CD16a (C-6His)
catalog :
CW91
quantity :
10 ug;50 ug;500 ug;1 mg
more info or order :
product information
Catalog Number :
CW91
Product Name :
Recombinant Cynomolgus CD16a (C-6His)
Product Type :
protein
Accession Number :
A0A140HDP8
Size :
10 ug;50 ug;500 ug;1 mg
List Price :
113
sku :
CW91-10ug
Size option :
10ug;50ug;500ug;1mg
Product Description :
Recombinant Cynomolgus Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A is produced by our Mammalian expression system and the target gene encoding Glu21-Gly206 is expressed with a 6His tag at the C-terminus.
Expression :
Human Cells
Background :
Receptors for the Fc region of immunoglobin G (FcγR) are divided into three classes and FcγRIII is a multifunctional, low/intermediate affinity receptor. In humans, FcγRIII is expressed as two distinct forms (FcγRIIIA and FcγRIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner. FcγRIIIB is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas FcγRIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. The FcγRIIIA receptor is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. FcγRIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia. In humans, it is a 50 -70 kD type I transmembrane activating receptor. The FcγRIIIA cDNA encodes 254 amino acid including a 16aa signal sequence, 191 amino acid ECD with two C2-type Ig-like domains, five potential N-glycosylation sites, a 22 amino acid transmembrane sequence and a 25 amino acid cytoplasmic domain.
Endotoxin :
Less than 0.1 ng/ug (1 EU/ug)
Formulation :
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Packaging :
Ambient
ALTnames :
Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; CD16a Antigen; Fc-Gamma RIII-Alpha; Fc-Gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc Receptor III-2; CD16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3
more info or order :
company information
Bon Opus Biosciences
150 Essex St. Suite 301
Millburn, NJ 07041
Millburn, NJ 07041
sales@bonopusbio.com
http://www.bonopusbio.com1-800-943-6396
headquarters: USA
Bon Opus Biosciences is a biotech company providing essential reagents to life science community. Bon Opus is derived from the Latin "Bonum Opus," which translates to good work. We are a team of like-minded and determined individuals, all sharing a vision for success. The catalog product includes primary antibody and recombinant proteins. The scope of services offered ranges from gene synthesis to recombinant protein expression, peptide synthesis, recombinant antibody production.
Every customer is our VIP:
Flat rate charge for gene synthesis, recombinant protein production
Our reagents, your discovery!
Every customer is our VIP:
Flat rate charge for gene synthesis, recombinant protein production
- Guaranteed quality
- Flexible and care
- Fast turnaround time
- Affordable cost
Our reagents, your discovery!