protein

Recombinant Human IL-23A & mouse IL-12B Heterodimer (C-6His)

CW81

10 ug;50 ug;500 ug;1 mg

Recombinant Human IL-23A & mouse IL-12B Heterodimer (C-6His)

protein

Q9NPF7&P43432

10 ug;50 ug;500 ug;1 mg

72

CW81-10ug

10ug;50ug;500ug;1mg

Recombinant Chimeric Human&Mouse Interleukin-23  is produced by our Mammalian expression system and the target gene encoding Arg20-Pro189&Met23-Ser335 is expressed with a 6His tag at the C-terminus.

Human Cells

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 um filtered solution of PBS,pH7.4

Ambient

SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2