protein

Recombinant Human OX40 (C-mFc)

CW26

10 ug;50 ug;500 ug;1 mg

Recombinant Human OX40 (C-mFc)

protein

P43489

10 ug;50 ug;500 ug;1 mg

95

CW26-10ug

10ug;50ug;500ug;1mg

Recombinant Human OX40L Receptor is produced by our Mammalian expression system and the targetgene encoding Leu29-Ala216 is expressed with a mFc tag at the C-terminus.

Human Cells

OX40, also termed CD134 andT NFRSF4, is a Tcellco-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells(APCs). TheT-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4

Ambient

Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; OX40L receptor; TAXtranscriptionally-activated glycoprotein 1 receptor; TNFRSF4; OX40; CD134; Txgp1