protein

Recombinant Mouse Angiopoietin-related Protein 3/ANGPTL3 (Ser17-Thr206)(C-6His)

CU60

10 ug;50 ug;500 ug;1 mg

Recombinant Mouse Angiopoietin-related Protein 3/ANGPTL3 (Ser17-Thr206)(C-6His)

protein

Q9R182

10 ug;50 ug;500 ug;1 mg

80

CU60-10ug

10ug;50ug;500ug;1mg

Recombinant Mouse Angiopoietin-related Protein 3 is produced by our Mammalian expression system and the target gene encoding Ser17-Thr206 is expressed with a 6His tag at the C-terminus.

Human Cells

Angiopoietin-like Protein 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins. Mature mouse ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. ANGPTL3 directly inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), enzymes responsible for hydrolyzing circulating triglycerides and HDL phospholipids. This activity requires a putative heparin-binding motif which is N-terminal to the coiled coil domain. Proteolytic removal of the fibrinogen-like domain from the N-terminal fragment serves to activate ANGPTL3 and increase its ability to inhibit LPL in vitro and function in vivo. ANGPTL3 promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion or uptake. ANGPTL3 expression in vivo is up-regulated by LXR agonists and down-regulated by insulin, leptin, and agonists of TRbeta or PPARbeta. ANGPTL3, secreted by fetal liver cells, also promotes the expansion of hematopoietic stem cells.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4

Ambient

Angiopoietin-related Protein 3; Angiopoietin-like protein 3; Angptl3