product summary
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company name :
Bon Opus Biosciences
product type :
protein
product name :
Recombinant Cynomolgus TIM-3/HAVCR2 (C-Fc)
catalog :
CS54
quantity :
10 ug;50 ug;500 ug;1 mg
more info or order :
Bon Opus Biosciences product webpage
product information
Catalog Number :
CS54
Product Name :
Recombinant Cynomolgus TIM-3/HAVCR2 (C-Fc)
Product Type :
protein
Accession Number :
G7P6Q7
Size :
10 ug;50 ug;500 ug;1 mg
List Price :
95
sku :
CS54-10ug
Size option :
10ug;50ug;500ug;1mg
Product Description :
Recombinant Cynomolgus T Cell Immunoglobulin and Mucin Domain-3 is produced by our Mammalian expression system and the target gene encoding Ser22-Arg201 is expressed with a Fc tag at the C-terminus.
Expression :
Mammalian cells
Background :
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
Endotoxin :
Less than 0.1 ng/ug (1 EU/ug)
Formulation :
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4
Packaging :
Ambient
ALTnames :
T cell immunoglobulin and mucin domain3; HAVCR2; Tim-3; TIM3
more info or order :
Bon Opus Biosciences product webpage
company information
Bon Opus Biosciences
150 Essex St. Suite 301
Millburn, NJ 07041
sales@bonopusbio.com
http://www.bonopusbio.com
1-800-943-6396
headquarters: USA
Bon Opus Biosciences is a biotech company providing essential reagents to life science community. Bon Opus is derived from the Latin "Bonum Opus," which translates to good work. We are a team of like-minded and determined individuals, all sharing a vision for success. The catalog product includes primary antibody and recombinant proteins. The scope of services offered ranges from gene synthesis to recombinant protein expression, peptide synthesis, recombinant antibody production.

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