product summary
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company name :
Bon Opus Biosciences
product type :
protein
product name :
Recombinant Mouse T-cell immunoreceptor with Ig and ITIM domains/TIGIT (C-Fc)
catalog :
CS15
quantity :
10 ug;50 ug;500 ug;1 mg
more info or order :
Bon Opus Biosciences product webpage
product information
Catalog Number :
CS15
Product Name :
Recombinant Mouse T-cell immunoreceptor with Ig and ITIM domains/TIGIT (C-Fc)
Product Type :
protein
Accession Number :
NP_001139797
Size :
10 ug;50 ug;500 ug;1 mg
List Price :
95
sku :
CS15-10ug
Size option :
10ug;50ug;500ug;1mg
Product Description :
Recombinant Mouse T-cell immunoreceptor with Ig and ITIM domains is produced by our Mammalian expression system and the target gene encoding Gly26 - Thr143 is expressed with a Fc tag at the C-terminus.
Expression :
Human Cells
Background :
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called WUCAM, VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.
Endotoxin :
Less than 0.1 ng/ug (1 EU/ug)
Formulation :
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4
Packaging :
Ambient
ALTnames :
T-cell immunoreceptor with Ig and ITIM domains; Tigit
more info or order :
Bon Opus Biosciences product webpage
company information
Bon Opus Biosciences
150 Essex St. Suite 301
Millburn, NJ 07041
sales@bonopusbio.com
http://www.bonopusbio.com
1-800-943-6396
headquarters: USA
Bon Opus Biosciences is a biotech company providing essential reagents to life science community. Bon Opus is derived from the Latin "Bonum Opus," which translates to good work. We are a team of like-minded and determined individuals, all sharing a vision for success. The catalog product includes primary antibody and recombinant proteins. The scope of services offered ranges from gene synthesis to recombinant protein expression, peptide synthesis, recombinant antibody production.

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