protein

Recombinant Mouse Signal-Regulatory Protein a-1/SIRPA/CD172a (C-6His)

CS12

10 ug;50 ug;500 ug;1 mg

Recombinant Mouse Signal-Regulatory Protein a-1/SIRPA/CD172a (C-6His)

protein

Q6P6I8

10 ug;50 ug;500 ug;1 mg

70

CS12-10ug

10ug;50ug;500ug;1mg

Recombinant Mouse Signal-Regulatory Protein alpha 1 is produced by our Mammalian expression system and the target gene encoding Lys32-Asn372 is expressed with a 6His tag at the C-terminus.

Human Cells

Mouse Signal Regulatory Protein (SIRP) is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRP can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRP acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRP shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRP engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4

Ambient

Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; SHP Substrate 1; Brain Ig-LikeMolecule with Tyrosine-Based Activation Motifs; CD172 Antigen-Like Family Member A; InhibitoryFeceptor SHPS-1; Macrophage Fusion Receptor;Signal-Regulatory Protein Alpha-1; Sirp-Alpha-1;Signal-Regulatory Protein Alpha-2; Sirp-Alpha-2; Signal-Regulatory Protein Alpha-3; Sirp-Alpha-3;CD172a; SIRPA; MFR; SHPS1; SIRP